Home >> Cantharidic Acid (sodium salt)
Related Products
Cantharidic Acid (sodium salt) PP1 and PP2A inhibitor

Catalog No.C3898
Size Price Stock Qty
10mg
$67.00
In stock
25mg
$157.00
In stock
50mg
$274.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

      

Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Cantharidic Acid (sodium salt)

Cantharidic Acid (sodium salt) Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Cantharidic Acid (sodium salt) Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Chemical Properties

Cas No. 1465-77-6 SDF Download SDF
Synonyms N/A
Chemical Name (1R,2S,3R,4S)-rel-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, disodium salt
Canonical SMILES OC([[email protected]@]1(C)[[email protected]](C(O)=O)(C)[[email protected]@H]2CC[[email protected]]1O2)=O.[Na+].[Na+]
Formula C10H12O5 • 2Na M.Wt 258.2
Solubility ≤2mg/ml in PBS(pH7.2) Storage Store at -20°C
Physical Appearance A crystalline solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Cantharidic acid, an inhibitor of protein phosphatases, is first isolated from Chinese blister beetles. Cantharidic acid is a hydrolysis product of cantharidin.

Protein phosphatases, account for virtually all of the phosphatase activity toward phosphoproteins, have been involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. Protein phosphatases participate in protein phosphorylation, a principal regulatory mechanism in the control of almost all cellular processes [2].

In vitro: Cantharidic acid exihibited inhibitory effects on the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 μM, respectively. Cantharidic acid showed no effect on the activity of PP2B or PP2C [1].

In vivo: Intraperitoneal administration of cantharidic acid (10 mg/kg) to mice for 45 min caused extreme liver enlargement and congestion. Treatment with cantharidic acid increased hepatic glycogenolysis, elevated blood glucose and hepatic glycogen phosphorylase levels, reduced hepatic glycogen content and glycogen synthase activity. Cantharidic acid endothal decreased microsomal Mg2+-ATPase levels [3].

References:
[1] McCluskey A, Sim A T R, Sakoff J A.  Serine threonine protein phosphatase inhibitors: Development of potential therapeutic strategies[J]. Journal of medicinal chemistry, 2002, 45(6): 1151-1175.
[2] Ingebritsen T S, Cohen P.  Protein phosphatases: properties and role in cellular regulation[J]. Science, 1983, 221(4608): 331-338.
[3] Graziano M J, Casida J E.  Comparison of the acute toxicity of endothal and cantharidic acid on mouse liver in vivo[J]. Toxicology letters, 1987, 37(2): 143-148.