Protein Ser/Thr Phosphatases
Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.
- A4542 Alexidine dihydrochlorideSummary: PTPMT1 inhibitor; PLB inhibitor
- A4543 BVT 948Summary: PTPs inhibitor,cell-permeable and non-competitve
- A4544 NSC 87877Target: PTPSummary: Shp2 /shp1 PTP inhibitor
- A4545 TCS 401Summary: Selective PTP1B inhibitor
- A8223 CID 2011756Summary: PKD inhibitor
- B3274 CCT007093Summary: PPM1D inhibitor
- B4846 LB-100Summary: protein phosphatase 2A(PP2A)inhibitor
- A8708 Sephin11 CitationTarget: phosphatasesSummary: Selective PPP1R15A inhibitor
- B5970 Sanguinarine chlorideSummary: Inhibitor of PP2C and MKP-1
- C3591 PTP Inhibitor IISummary: protein tyrosine phosphatase (PTP) inhibitor