Tautomycetin
Tautomycetin (CAS 119757-73-2) is a small-molecule inhibitor targeting serine/threonine protein phosphatase type 1 (PP1). It exhibits high selectivity for PP1, with reported IC50 values of 1.6 nM for PP1 and 62 nM for PP2A. PP1 is integral to various fundamental cellular processes, including transcriptional regulation, protein synthesis, mitosis, muscle contraction, glycogen metabolism, and neuronal signaling pathways. Due to its selectivity, Tautomycetin is particularly useful for dissecting PP1-specific regulatory roles in biochemical and cellular research contexts.
| Physical Appearance | Colourless liquid |
| Storage | Desiccate at -20°C |
| M.Wt | 606.75 |
| Cas No. | 119757-73-2 |
| Formula | C33H50O10 |
| Solubility | Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml) |
| Chemical Name | (S)-(2S,3S,4R,7S,8R,11R,13R,Z)-17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxononadeca-16,18-dien-2-yl 3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoate |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H]([C@H](C)C(C[C@H]([C@H](C)[C@H](C)OC(C[C@@H](C1=C(C)C(OC1=O)=O)O)=O)O)=O)CC[C@@H](C)C[C@@H](C)CC(/C=C(C=C)/CC)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Human primary T cells |
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Preparation method |
The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
1 μg/ml for 5 h |
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Applications |
Tautomycetin possesses immunosuppressive activity to inhibit the proliferation of T cells by inhibition of IL-2 secretion. |
| Animal experiment [1]: | |
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Animal models |
Rats after heterotopic cardiac transplantation |
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Dosage form |
0.05 mg/kg. Tautomycetin solubilized in PBS or in microemulsion form for 30 days after heterocardiac transplantation. |
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Application |
Immunosuppressive activity of tautomycetin is effective in an in vivo organ transplantation model (rats after heterotopic cardiac transplantation). |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1] Jae-Hyuck Shim, et al. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc Natl Acad Sci U S A. 2002 Aug 6; 99(16): 10617–10622. | |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
