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Signaling Pathways

Signaling Pathways

A4511 Cercosporamide

Target: JAK|MNK

Summary: Mnk2 and JAK3 inhibitor

soluble in DMSO
A4512 Cucurbitacin I

Target: STAT|JAK

Summary: STAT3/JAK2 signaling inhibitor

≥22.45 mg/mL
B1130 GLPG0634
1 Citation

Target: JAK

Summary: JAK1 inhibitor

≥21.3 mg/mL
A3012 Ruxolitinib (INCB018424)
4 Citation

Target: JAK

Summary: JAK inhibitor

insoluble in H2O; ≥15.32 mg/mL
A4135 Tofacitinib (CP-690550) Citrate
2 Citation

Target: JAK

Summary: Potent JAK inhibitor

≥25.22 mg/mL
A4136 TG101348 (SAR302503)
2 Citation

Target: FLT3|JAK|c-RET

Summary: JAK-2 inhibitor,potent and selective

≥26.23 mg/mL
A4137 AZD1480

Target: JAK

Summary: JAK2 inhibitor,ATP-competitive and novel

insoluble in H2O; ≥93.8 mg/mL
A4138 Tofacitinib (CP-690550,Tasocitinib)
1 Citation

Target: JAK

Summary: Janus kinase inhibitor

insoluble in EtOH; insoluble in H2O; ≥15.6 mg/mL
A4139 AG-490
3 Citation

Target: EGFR|JAK

Summary: JAK2/EGFR inhibitor

insoluble in H2O; ≥14.7 mg/mL
A4140 WP1066

Target: STAT|JAK

Summary: JAK2/STAT3 inhibitor,cell-permeable

insoluble in H2O; ≥17.8 mg/mL