D-Luciferin
Catalog No.
B6040
cell-permeable chemiluminescent luciferase substrate
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D-Luciferin (CAS 2591-17-5) is a membrane-permeable bioluminescent substrate for firefly luciferase, characterized by a Km of approximately 2 μM. In the presence of ATP, luciferin undergoes oxidation and decarboxylation catalyzed by luciferase, emitting measurable photons. This bioluminescence enables quantification of intracellular ATP levels both in vitro and in vivo. In biomedical research, D-Luciferin is commonly applied for monitoring promoter-driven luciferase gene expression and as a non-invasive imaging probe in bioluminescence imaging (BLI) studies to assess tumor burden, pharmacodynamics, and cellular ATP content.
- 1. Shu Chen, Xi Zhang, et al. "TFF3 facilitates dormancy of anti-estrogen treated ER+ mammary carcinoma." Commun Med (Lond). 2025 Feb 21;5(1):45. PMID: 39984660
- 2. Jing Zhou, Xinyue Wang, et al. "PIM1 kinase promotes EMT-associated osimertinib resistance via regulating GSK3β signaling pathway in EGFR-mutant non-small cell lung cancer." Cell Death Dis. 2024 Sep 3;15(9):644. PMID: 39227379
- 3. Kang-Jing Li, Yaying Hong, et al. "NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating mRNAs of HMGA1 and KRT8." Adv Sci (Weinh). 2024 Jun 23:e2310131. PMID: 38922788
- 4. Cheng Qian, jiatao li, et al. "B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibition tumor infiltrating CD4+T cell cytotoxicity through ESM1." Research Square. 30 Nov, 2023
- 5. Le Wen, Xian-Zhang Wang, et al. "SOX2 downregulation of PML increases HCMV gene expression and growth of glioma cells." PLoS Pathog. 2023 Apr 14;19(4):e1011316. PMID: 37058447
- 6. Tao Xie, Du-Jiang Fu, et al. "CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling." Mol Cancer. 2022 Sep 1;21(1):173. PMID: 36045408
- 7. Libin Zou, Wenbin Chen, et al. "N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability." Cell Death Discov. 2022 Apr 9;8(1):184. PMID: 35397614
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 280.32 |
| Cas No. | 2591-17-5 |
| Formula | C11H8N2O3S2 |
| Solubility | ≥28 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | (S)-2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | OC1=CC(S2)=C(N=C2C3=N[C@](C(O)=O)([H])CS3)C=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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