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Oligomycin A

Catalog No.
A5588
Mitochondrial ATP synthase Inhibitor
Grouped product items
SizePriceStock Qty
5mg
$263.00
In stock
10mg
$470.00
In stock
25mg
$706.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Oligomycin A (CAS 579-13-5) is a potent inhibitor of mitochondrial ATP synthase, specifically targeting the proton channel of the enzyme's F0 subunit. By blocking proton translocation, oligomycin A effectively halts ATP production via oxidative phosphorylation, thereby substantially reducing electron transport chain activity and cellular oxygen consumption. Experimental studies in cancer cell models demonstrate oligomycin A's ability to rapidly suppress mitochondrial respiration at low concentrations, causing significant metabolic shifts toward glycolysis. Consequently, oligomycin A is frequently utilized in biomedical research to elucidate mitochondrial bioenergetics, apoptosis pathways, and metabolic adaptations in cancer.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt791.06
Cas No.579-13-5
FormulaC45H74O11
Solubilityinsoluble in H2O; ≥17.43 mg/mL in EtOH; ≥9.89 mg/mL in DMSO
Chemical Name4-ethyl-11,12,15,19-tetrahydroxy-6'-(2-hydroxypropyl)-5',10,12,14,16,18,20,26,29-nonamethylspiro[24,28-dioxabicyclo[23.3.1]nonacosa-5,7,21-triene-27,2'-oxane]-13,17,23-trione
SDFDownload SDF
Canonical SMILESCCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment[1]:

Cell lines

Human laryngeal cancer docetaxel-resistant DRHEp2 cells

Preparation method

The solubility of this compound in DMSO is > 9.9mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

72 h, 2 µg/ml

Applications

Oligomycin A is an Fo-ATPase inhibitor. Oligomycin A increased the sensitivity of DRHEp2 cells to docetaxel in a dose-dependent manner and combining oligomycin A and docetaxel increased the generation of mitochondrial ROS.

References:

[1]. Mizumachi T, Suzuki S, Naito A, et al. Increased mitochondrial DNA induces acquired docetaxel resistance in head and neck cancer cells[J]. Oncogene, 2008, 27(6): 831-838.

Quality Control

Quality Control & MSDS

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Chemical structure

Oligomycin A

Related Biological Data

Oligomycin A