L-Glutathione Reduced
L-Glutathione Reduced is an endogenous antioxidant, with the ability to scavenge oxygen-derived free radicals. L-Glutathione Reduced is a non-protein thiol widely present in living cells, which plays an important role in a series of biological events, including protein and DNA synthesis, enzyme activity, metabolism as well as cell protection. Not only does L-Glutathione Reduced scavenge oxygen-derived free radicals which contribute to the development of many common diseases including cancer, heart attack, stroke, arthritis, but it also helps in regenerating other antioxidants such as vitamin E and ascorbic acid. Thus, L-Glutathione Reduced is established to be a marker of oxidative stress. In addition, L-Glutathione Reduced is used for eluting glutathione S-transferase (GST) from glutathione agarose.
Reference:
1. Pereira-Rodrigues N, Cofré R, Zagal JH, et al. Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced L-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH. Bioelectrochemistry, 2007, 70(1): 147-154.
- 1. Ziyi Dong, Qin Zhang, et al. "Enhancing tumor penetration: GSH-sensitive paclitaxel liposomes modified with Dermaseptin-PP." Materials & Design Volume 246, October 2024, 113323
- 2. Mengting Zhang, Wanhong Wu, et al. "Interaction of Bmal1 and eIF2α/ATF4 pathway was involved in Shuxie compound alleviation of circadian rhythm disturbance-induced hepatic endoplasmic reticulum stress." J Ethnopharmacol. 2023 Aug 10:312:116446. PMID: 37019162
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 307.32 |
| Cas No. | 70-18-8 |
| Formula | C10H17N3O6S |
| Solubility | insoluble in EtOH; insoluble in DMSO; ≥14.25 mg/mL in H2O |
| Chemical Name | (S)-2-amino-5-(((R)-1-((carboxymethyl)amino)-3-mercapto-1-oxopropan-2-yl)amino)-5-oxopentanoic acid |
| SDF | Download SDF |
| Canonical SMILES | SC[C@@H](C(NCC(O)=O)=O)NC(CC[C@@H](C(O)=O)N)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Animal experiment [1]: | |
|
Animal models |
Male Hypothyroidism Wistar rats |
|
Dosage form |
0.0012%, oral administration |
|
Application |
Compared with the control group, no significant effects were observed in the rates of lipid peroxidation and vitamin E in hepatic and cardiac tissues of hypothyroidism rats, while the thyroid function of hyperthyroidism rats was significantly enhanced. |
|
Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
|
References: [1]. Messarah M, Boulakoud MS, Boumendjel A, Abdennour C, El Feki A. The impact of thyroid activity variations on some oxidizing-stress parameters in rats. C R Biol. 2007 Feb;330(2):107-12. Epub 2006 Dec 12. PubMed PMID: 17303537. |
|
Quality Control & MSDS
- View current batch:
Chemical structure
