Kaempferol
- 1. Hairong Li, lijun Niu, et al. "Mechanism investigation of anti-NAFLD of Shugan Yipi Granule based on network pharmacology analysis and experimental verification." August 01, 2024.
- 2. Qing Zhu, Yuanshan Han, et al. "Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway." Front Biosci (Landmark Ed). 2023 Nov 28;28(11):311. PMID: 38062826
- 3. Wenling Tu, Yinjie Hong, et al. "Effect of kaempferol on hedgehog signaling pathway in rats with --chronic atrophic gastritis – Based on network pharmacological screening and experimental verification." Biomed Pharmacother. 2022 Jan;145:112451. PMID: 34839256
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 286.24 |
| Cas No. | 520-18-3 |
| Formula | C15H10O6 |
| Synonyms | Kempferol |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥12.25 mg/mL in DMSO |
| Chemical Name | 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
The human cholangiocarcinoma (CCA) cell lines HCCC9810 and QBC939 |
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Preparation method |
The solubility of this compound in DMSO is >12.3mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
0, 30, 60, 90, 120, or 150 μM; 24, 48, or 72 h; 37°C |
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Applications |
In CCA cells, kaempferol significantly inhibited the viability and proliferation of CCA cells in a time- and dose-dependent way. Kaempferol reduced the number of colonies and induced apoptosis in a dose-dependent way. Kaempferol also reduced the migration and invasion ability of CCA cells in a dose-dependent manner. |
| Animal experiment [1]: | |
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Animal models |
subcutaneous xenograft nude mice model |
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Dosage form |
20 mg/kg/day; daily for 3 weeks; i.p. |
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Application |
In subcutaneous xenograft nude mice model, kaempferol significantly inhibited the growth of the tumor. The number of Ki-67-positive tumor cells was lower in kaempferol-treated group than that in the control group. Kaempferol reduced the average volume and number of foci per mouse. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Qin Y1, Cui W2, Yang X2, et al. Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2016 Mar;48(3):238-45. | |
Quality Control & MSDS
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Chemical structure
Related Biological Data
