Fludarabine Phosphate (Fludara)|Inhibits STAT1 activation and DNA synthesis|CAS# 75607-67-9

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Size	Price	Stock
10mM (in 1mL DMSO)	$50.00	In stock
Evaluation Sample	$28.00	In stock
10mg	$69.00	In stock
50mg	$219.00	In stock
200mg	$420.00	In stock

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Quality Control

Quality Control & MSDS

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Purity = 98.54%

Chemical structure

Biological Activity

Description	Fludarabine is an inhibitor of STAT1 activation and a DNA synthesis.
Targets	DNA synthesis
IC50

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Chemical Properties

Cas No.	75607-67-9	SDF	Download SDF
Synonyms	Fludura
Chemical Name	[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Canonical SMILES	C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(N=C2N)F
Formula	C₁₀H₁₃FN₅O₇P	M.Wt	365.21
Solubility	>17.6mg/mL in DMSO	Storage	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

Background

Fludarabine phosphate is a STAT-1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.