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FK 866 hydrochloride

Catalog No.
A8631
NMPRTase inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$72.00
In stock
5mg
$66.00
In stock
10mg
$121.00
In stock
25mg
$275.00
In stock
50mg
$429.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

FK 866 hydrochloride (CAS: 658084-64-1, free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase), an enzyme essential for NAD biosynthesis, exhibiting activity with IC50 values ranging from 0.09 nM to 27.2 nM. By blocking NAD synthesis, FK 866 disrupts ATP production, induces mitochondria membrane depolarization, and triggers autophagy independent of caspase activation. It selectively targets hematologic cancer cells, such as AML lines, sparing normal hematopoietic progenitor cells. FK 866 demonstrates antitumor efficacy in vivo, significantly suppressing growth in AML-M4 and Namalwa xenograft models.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt427.97
Cas No.658084-64-1 (free base)
FormulaC24H30ClN3O2
Solubility≥18.95 mg/mL in DMSO; ≥21 mg/mL in EtOH; ≥9.8 mg/mL in H2O
Chemical Name(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide hydrochloride
SDFDownload SDF
Canonical SMILESO=C(NCCCCC1CCN(C(C2=CC=CC=C2)=O)CC1)/C=C/C3=CC=CN=C3.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

FK 866 hydrochloride