FK 866 hydrochloride
Catalog No.
A8631
NMPRTase inhibitor
Featured Products
FK 866 hydrochloride (CAS: 658084-64-1, free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase), an enzyme essential for NAD biosynthesis, exhibiting activity with IC50 values ranging from 0.09 nM to 27.2 nM. By blocking NAD synthesis, FK 866 disrupts ATP production, induces mitochondria membrane depolarization, and triggers autophagy independent of caspase activation. It selectively targets hematologic cancer cells, such as AML lines, sparing normal hematopoietic progenitor cells. FK 866 demonstrates antitumor efficacy in vivo, significantly suppressing growth in AML-M4 and Namalwa xenograft models.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 427.97 |
| Cas No. | 658084-64-1 (free base) |
| Formula | C24H30ClN3O2 |
| Solubility | ≥18.95 mg/mL in DMSO; ≥21 mg/mL in EtOH; ≥9.8 mg/mL in H2O |
| Chemical Name | (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | O=C(NCCCCC1CCN(C(C2=CC=CC=C2)=O)CC1)/C=C/C3=CC=CN=C3.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
