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amyloid A protein fragment [Homo sapiens]

Catalog No.
A1053
Apolipoproteins related to HDL in plasma
Grouped product items
SizePriceStock Qty
1mg
$50.00
In stock
5mg
$150.00
In stock
10mg
$250.00
In stock
25mg
$350.00
In stock

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Email: [email protected]

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Background

Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH), also called Serum amyloid A (SSA) proteins, are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma. Different isoforms of SAA are expressed constitutively (constitutive SAAs) at different levels or in response to inflammatory stimuli (acute phase SAAs).

These proteins are produced predominantly by the liver. [1] The conservation of these proteins throughout invertebrates and vertebrates suggests that SAAs play a highly essential role in all animals. [2]

Serum amyloid A (SAA) is also an acute phase marker that responds rapidly. Like CRP, levels of acute-phase SAA increase within hours after an inflammatory stimulus, but the magnitude of increase may be greater than that of CRP. Relatively trivial inflammatory stimuli can lead to SAA responses. It has been suggested that SAA levels correlate better with disease activity in early inflammatory joint disease than do ESR and CRP levels. Although SAA is largely produced by hepatocytes, more recent studies show that SAA is also produced by adipocytes and that its serum concentration is associated with body mass index. [3]

Ref:

1. Uhlar CM, Whitehead AS (1999). "Serum amyloid A, the major vertebrate acute-phase reactant". Eur. J. Biochem. 265 (2): 501–23. Fei, DTW. et al. (1980) Life Sci. 27, 1495.

2. Manley PN, Ancsin JB, Kisilevsky R (2006). "Rapid recycling of cholesterol: the joint biologic role of C-reactive protein and serum amyloid A". Med. Hypotheses 66 (4): 784–92.

3. Zhang N, Ahsan MH, Purchio AF, West DB (2005). "Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition". J. Immunol. 174 (12): 8125–34.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt776.88
FormulaC36H56N8O11
SynonymsH2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH
Solubility≥77.7mg/mL in DMSO
SDFDownload SDF
Canonical SMILESCC(N)C(NCC(NC(C(N1CCC[[email protected]@H]1C(NC(C(NC(CCCCN)C(N[[email protected]@H](CC2=CC=C(O)C=C2)C(O)=O)=O)=O)CCC(O)=O)=O)=O)CC(C)C)=O)=O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

amyloid A protein fragment [Homo sapiens]