Xylazine HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Xylazine HCl is a strong agonist of α2-adrenoceptor [1].
Xylazine HCl has been reported to stimulate the proliferation of rat thymocytes in vivo (at doses of 2.5 mg/kg and 5 mg/kg) and in vitro (at concentration of 5 mM) [2]. In the analgesic testing, Xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. In addition, Xylazine has also shown the inhibitory effect in the mouse vas deferens bioassay with the IC50 value of 18nM. Furthermore, Xylazine has displayed a potent specific [3H]-dihydromorphine binding inhibition with the IC50 value of 8μM in opiate receptor binding test [1].
References:
[1] S. BROWNING, D.LAWRENCE1, A.LIVINGSTON & B.MORRIS. Interaction of drugs active at opiate receptors and drugs active at α2-adrenoceptors on various test systems
[2] Colić M1, Cupić V, Pavicić L, Vucević D, Varagić VM. Xylazine, an alpha 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. Methods Find Exp Clin Pharmacol. 2000 Sep;22(7):557-62.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 256.79 |
| Cas No. | 23076-35-9 |
| Formula | C12H16N2S·HCl |
| Solubility | ≥12.84 mg/mL in DMSO; ≥24.1 mg/mL in EtOH; ≥24.15 mg/mL in H2O |
| Chemical Name | N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(C(=CC=C1)C)NC2=NCCCS2.Cl |
| Shipping Condition | Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
Quality Control & MSDS
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Chemical structure
