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vitamin D binding protein precursor (353-363) [Homo sapiens]

vitamin D binding protein precursor (353-363) [Homo sapiens]

Catalog No. A1099
Size Price Stock Qty
1mg $50.00 In stock
5mg $150.00 In stock
10mg $250.00 In stock
25mg $350.00 In stock

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we offer trial solution enough for 3-5 experiments.

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Chemical structure

vitamin D binding protein precursor (353-363) [Homo sapiens]

vitamin D binding protein precursor (353-363) [Homo sapiens] Dilution Calculator

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Chemical Properties

Cas No. SDF Download SDF
Chemical Name vitamin D binding protein precursor (353-363) [Homo sapiens]
Formula C61H99N17O16 M.Wt 1326.54
Solubility Storage Store at -20°C

Background

Human vitamin D-binding protein (hDBP),' also known as Gcglobulin, is an abundant, multifunctional, and highly polymorphic serum glycoprotein synthesized by the liver1.  DBP is the major serum transport protein for the vitamin D sterols2, binds and sequesters monomers of actin with high affinity3, 4, and has been identified on the surface of a variety of cell types including B-lymphocytes5, subpopulations of T-lymphocytes6, and the cytotrophoblasts of the placenta7.

DBP is a secreted protein and would therefore be predicted to have a signal sequence. The amino-terminus of the mature serum protein was established by aligning the sequence predicted by the cDNA to a sequenced amino-terminal hDBP peptide8.

 C61H99N17O16

A1099_1

Figure1. Structure of Vitamin D binding protein

 A1099_2

Figure2. Formula of Vitamin D binding protein precursor (353-363)

Ref:

1.Haddad, J. G. 1979. Transport of vitamin D metabolites. Clin. Orthop. Relat. Res. 142:249-274.

2.Daiger, S. P., M. S. Schanfield, and L. L. Cavalli-Sforza. 1975. Group specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Proc. Natl. Acad. Sci. USA. 72:2076-2080.

3.Cooke, N. E., J. Walgate, and J. G. Haddad. 1979. Human serum binding protein for vitamin D and its metabolites. I. Physicochemical and immunological identification in human tissues. J. Biol. Chem. 254: 5965-5971.

4.Van Baelen, H., R. Bouillon, and P. DeMoor. 1980. Vitamin D binding protein (Gc-Globulin) binds actin. J. Biol. Chem. 255:2270-2272.

5.Petrini, M., D. L. Emerson, and R. M. Galbraith. 1983. Linkage between surface immunoglobulin and cytoskeleton of B lymphocytes may involve Gc protein. Nature (Lond.). 306:73-74.

6.Petrini, M., R. M. Galbraith, D. L. Emerson, A. E. Nel, and P. Arnaud. 1985. Structural studies of T lymphocyte Fc receptors. J. Biol. Chem. 260:1804-1810.

7.Nestler, J. E., E. Lange, J. McLeod, H. J. Kliman, and J. F. Strauss. 1985. Detection of vitamin D binding protein (DBP) in human cytotrophoblasts. Seventh Annual American Societyfor Bone and Mineral Research. Wash. DC. 266a. (Abstr.).

8.Svasti, J., A. Kurosky, A. Bennett, and B. H. Bowman. 1979. Molecular basis for the three major forms of human serum vitamin D binding protein (group specific component). Biochemistry. 18:1611-1617.