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Valinomycin

Catalog No.
B7388
potassium-specific transporter
Grouped product items
SizePriceStock Qty
25mg
$88.00
Ship with 5-10 days
50mg
$164.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

LD50 = 2.5 mg/kg for mouse and 5 mg/kg for rabbit [1]

Valinomycin is a dodecadepsipeptide antibiotic, which is obtained from several Streptomyces strains. Valinomycin functions as a potassium-specific transporter and promotes the movement of K+ through lipid membranes. Excessive K+ efflux is an ionic mechanism underlying apoptosis.

In vitro: Valinomycin caused substantial CHO cells death within 12 h of treatment. Several apoptotic events were identified in valinomycin-treated CHO cells, including caspase-3 activation, phosphatidylserine (PS) membrane translocation, and mitochondrial membrane depolarization during the first few hours of treatment. K+ efflux was reduced by elevating extracellular K+ concentrations [2].

In vivo: Valinomycin is irritant in the case of eye and skin contact. Inhalation of valinomycin can cause breathing disturbances and even loss of conscious. Lethal doses (LD50) for mouse and rabbit is 2.5 mg/kg and 5 mg/kg respectively. Valinomycin also shows to provoke lots of chronic effects, including damage of the central and peripheral nervous system, eyes, lens and cornea [1].

Clinical trial: Because valinomycin’s toxicity to eukaryotic cells, it can not be used in human therapy [1].

References:
[1] Kroteń MA, Bartoszewicz M, Swiecicka I.  Cereulide and valinomycin, two important natural dodecadepsipeptides with ionophoretic activities. Pol J Microbiol. 2010;59(1):3-10.
[2] Abdalah R1, Wei L, Francis K, Yu SP.  Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett. 2006 Sep 11;405(1-2):68-73. Epub 2006 Jul 20.

Chemical Properties

Physical AppearanceA crystalline solid
StorageDesiccate at -20°C
M.Wt1111.32
Cas No.2001-95-8
FormulaC54H90N6O18
SolubilitySoluble in DMSO
Chemical Name(3S,6R,9R,12S,15S,18S,21R,24R,27R,30R,33R,36S)-3,6,9,15,18,21,27,30,33-nonaisopropyl-12,24,36-trimethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecaone
SDFDownload SDF
Canonical SMILESO=C([[email protected]@H](C(C)C)OC([[email protected]@H](C(C)C)NC1=O)=O)N[[email protected]@H](C(O[[email protected]](C)C(N[[email protected]@H](C(O[[email protected]](C(N[[email protected]](C(O[[email protected]@H](C)C(N[[email protected]@H](C(O[[email protected]@H](C(N[[email protected]](C(O[[email protected]]1C)=O)C(C)C)=O)C(C)C)=O)C(C)C)=O)=O)C(C)C)=O)C(C)C)=O)C(C)C)=O)=O)C(C)C
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Valinomycin