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TWS119

Catalog No.
B1540
GSK-3β inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$110.00
In stock
10mg
$85.00
In stock
20mg
$150.00
In stock
50mg
$330.00
Ship with 10-15 days
100mg
$470.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

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Background

TWS119 is an inhibitor of glycogen synthase kinase-3β (GSK-3β) with IC50 value of 30nM [1].

TWS119 is screened out from a library of pyrrolopyrimidines as a molecule that selectively induces neuronal differentiation when using mouse P19 EC cells. TWS119 binds to GSK-3β tightly with a Kd value of 126nM and shows an inhibition with IC50 value of 30nM. The combination of TWS119 and GSK-3β modulates the activity of the complex and triggers downstream transcriptional events lead the neuronal induction. Besides that, TWS119 promotes neuronal differentiation of mESCs through another mechanism but not the canonical Wnt signaling pathway [1, 2].

References:
[1] Ding S, Wu T Y H, Brinker A, et al. Synthetic small molecules that control stem cell fate. Proceedings of the National Academy of Sciences, 2003, 100(13): 7632-7637.
[2] Wu T Y H, Ding S. Applying chemical tools to the discovery of novel regenerative medicine. Drug Discovery Today: Technologies, 2006, 3(3): 255-260.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt318.33
Cas No.601514-19-6
FormulaC18H14N4O2
Solubility≥15.9mg/mL in DMSO
Chemical Name3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
SDFDownload SDF
Canonical SMILESC1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description TWS119 is a GSK-3β inhibitor with an IC50 value of 30 nM.
Targets GSK-3β          
IC50 30 nM          

Quality Control

Quality Control & MSDS

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Chemical structure

TWS119

Related Biological Data

TWS119