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(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane
PAF receptor antagonist

Catalog No.C5389
Size Price Stock Qty
5mg
$163.00
In stock
10mg
$290.00
In stock

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Sample solution is provided at 25 µL, 10mM.

(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane Dilution Calculator

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(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane Molarity Calculator

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Chemical Properties

Cas No. 116673-45-1 SDF Download SDF
Synonyms trans-BTP Dioxolane
Chemical Name trans-(±)-2,4-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane
Canonical SMILES COC1=CC([[email protected]]2O[[email protected]](C3=CC(OC)=C(OC)C(OC)=C3)OC2)=CC(OC)=C1OC
Formula C21H26O8 M.Wt 406.4
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane, also known as trans-BTP Dioxolane, is a PAF receptor antagonist [1].

Platelet activating factor (PAF), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1].

(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane is a PAF receptor antagonist. In the rabbit washed platelet assay, (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane showed good competitive PAF antagonism with Ki value of 0.3 μM, whereas the cis-isomer was much less active.

Reference:
[1].  Corey, E.J.,Chen, C.P., and Parry, M.J. Dual binding modes to the receptor for platelet activating factor (PAF) of anti-PAF trans-2,5-diarylfurans. Tetrahedron Letters 29, 2899-2902 (1988).