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β-Tocotrienol

Catalog No.
C5523
antioxidant
Grouped product items
SizePriceStock Qty
1mg (solution)
$78.00
Ship with 5-10 days
5mg (solution)
$273.00
Ship with 5-10 days
10mg (solution)
$507.00
Ship with 5-10 days
25mg (solution)
$1,168.00
Ship with 5-10 days

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Email: [email protected]

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Background

β-Tocotrienol is an antioxidant.

There are four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) forms of vitamin E, which is known for its antioxidant activity. Tocotrienols are present in high concentrations in palm oil and wheat germ.

In vitro: The antioxidant activity of the tocopherols and tocotrienols was found to be mainly due to their ability to donate their phenolic hydrogens to lipid free-radicals. Although it is generally agreed that the relative antioxidant activity of the tocopherols was in the order α>β>γ>δ [1].

In vivo: In a previous study, mice were fed a nonpurified control diet, an atherogenic diet alone or the atherogenic diet supplemented with α- and β-tocopherols. Results showed that compared with mice fed the control diet, plasma cholesterol was fourfold greater in mice fed the atherogenic diet. Mice fed the atherogenic diet had much higher VLDL, intermediate density lipoprotein (IDL) and LDL cholesterol and markedly lower HDL cholesterol than the controls. Moreover, in mice fed the atherogenic diet, the hepatic cholesterol plus cholesterol ester concentration was 4.4-fold greater than in mice fed the control diet. Mice fed the atherogenic diet had large atherosclerotic lesions at the level of the aortic valve. The 0.5 g/100 g alpha-tocopherol and palm carotenoid supplements had no effect [2].

Clinical trial: So far, no clinical study has been conducted.

References:
1.  Kamal-Eldin, A., and Appelqvist, L.. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31, 671-701 (1996).
2.  Black, T.M.,Wang, O.,Maeda, N., et al. Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. Journal of Nutrition 130(10), 2420-2426 (2000).

Chemical Properties

Physical AppearanceA solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
StorageStore at -20°C
M.Wt410.6
Cas No.490-23-3
FormulaC28H42O2
Solubility≤10mg/ml in DMSO;10mg/ml in dimethyl formamide
Chemical Name(2R)-3,4-dihydro-2,5,8-trimethyl-2-[4,8,12-trimethyl-3E,7E,11-tridecatrien-1-yl]-2H-1-benzopyran-6-ol
SDFDownload SDF
Canonical SMILESC[[email protected]]1(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)OC2=C(C)C=C(O)C(C)=C2CC1
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Protocol

Animal experiment [1]:

Animal models

ApoE+/- female mice

Dosage form

0.5 g/100 g palm tocopherols (palm-E; 33% alpha-tocopherol, 16.1% alpha-tocotrienol, 2.3% beta-tocotrienol, 32.2% gamma-tocotrienol, 16.1% delta-tocotrienol)

Application

In previous studies, mice were fed an unpurified control diet, either an atherogenic diet alone or an atherogenic diet supplemented with α- and β-tocopherol. The results showed that mice fed the atherogenic diet had four times higher plasma cholesterol compared to mice fed the control diet.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Black TM, Wang P, Maeda N, Coleman RA. Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. J Nutr. 2000 Oct;130(10):2420-6. doi: 10.1093/jn/130.10.2420. PMID: 11015467.