Toggle Nav
Close
  • Menu
  • Setting

Tin protoporphyrin IX dichloride

Catalog No.
B6432
heme oxygenase inhibitor
Grouped product items
SizePriceStock Qty
10mg
$103.00
Ship with 5-10 days
25mg
$244.00
Ship with 5-10 days
50mg
$432.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Tin protoporphyrin IX dichloride is a synthetic heme analog that selectively inhibits heme oxygenase 2 (HO-2) with IC50 value of 7.5 µM [1]. 

HO-2, widely expressed with high concentrations in the brain, is one of two forms of HO (HO-1 and HO-2). HO is responsible for converting heme to biliverdin, and carbon monoxide (CO), which has been implicated as a biological messenger molecule analogous to nitric oxide (NO) with endothelial-derived relaxing activity [1]. 

Tin protoporphyrin IX dichloride is a selective inhibitor of HO with ~ 10-fold selectivity for HO over endothelial nitric oxide synthase (NOS) and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). Tin protoporphyrin IX dichloride (1 ~ 100 µM) reduced acetylcholine (Ach)-induced endothelial-derived relaxation of porcine distal pulmonary arteries in the presence of Nw-nitro-Larginine methyl ester (L-NAME), with an IC50 of 7.6 µM [1]. 

In Sprague-Dawley rat neonates, a single subcutaneous injection of Tin protoporphyrin IX dichloride (100 µmol/kg) at birth, 12, 24, 48, and 72 hr later, blocked the postnatal increase in heme oxygenase activity that occurs in various tissues. Tin protoporphyrin IX dichloride administration also entirely prevented the development of hyperbilirubinemia that normally occurs postnatally [2]. 

References:

[1]. Zakhary R, Gaine S P, Dinerman J L, et al. Heme oxygenase 2: Endothelial and neuronal localization and role in endothelium-dependent relaxation. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93(2): 795-798.

[2]. Drummond G S, Kappas A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proceedings of the National Academy of Sciences of the United States of America, 1981, 78(10): 6466-6470.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt750.25
Cas No.14325-05-4
FormulaC34H32Cl2N4O4Sn
Solubilityinsoluble in EtOH; insoluble in H2O; ≥22.15 mg/mL in DMSO
SDFDownload SDF
Canonical SMILESC=CC1=C(/C2=C([H])/C(C(C)=C/3CCC([O-])=O)=NC3=C([H])/C4=N/C(C(C)=C4CCC([O-])=O)=C([H])\C5=C(C(C)=C([N-]5)/C([H])=C1\[N-]2)C=C)C.Cl.Cl.[Sn+4]
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Tin protoporphyrin IX dichloride