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Tetracycline Hydrochloride

Catalog No.
A2517
Bacteriostatic antibiotics
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
1g
$42.00
In stock
5g
$76.00
In stock

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Background

Tetracycline Hydrochloride is an inhibitor of bacterial ribosomes [1]. 

Tetracycline Hydrochloride is believed to inhibit translation by binding to the 16S rRNA and inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. However, the exact target site(s) and mechanism(s) of action remain subjects of much debate [1]. 

Tetracycline Hydrochloride at doses of 0, 10, 25, 50, 75, 150, 225 and 300 µM exhibited increasing antimicrobial effect against resistant strains of Staphylococcus aureus (S. aureus). The statistically evaluated IC50 values of Tetracycline Hydrochloride against S. aureus, cadmium-resistant S. aureus, and lead-resistant S. aureus after first 6 h were 4.8, 3.8, 2.2 µM, respectively [2]. 

In humans who had minimum Propionibacterium acnes (P. acnes) levels of 10000 colony-forming units per cm2 at baseline, Tetracycline Hydrochloride treatment (1000 mg/d, b.i.d., p.o.) over a 6-week period significantly reduced P. acnes on both cheeks and forehead after 3 and 6 weeks, but produced little to no residual effect. At 9 weeks, P. acnes levels in the Tetracycline Hydrochloride group had returned to baseline [3]. 

References:

[1]. Chukwudi C U. rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines. Antimicrobial Agents and Chemotherapy, 2016, 60(8): 4433-4441.

[2]. Chudobova D, Dostalova S, Blazkova I, et al. Effect of ampicillin, streptomycin, penicillin and tetracycline on metal resistant and non-resistant Staphylococcus aureus. International Journal of Environmental Research and Public Health, 2014, 11(3): 3233-3255.

[3]. Leyden J J, Kaidbey K, Gans E H. The antimicrobial effects in vivo of minocycline, doxycycline and tetracycline in humans. Journal of Dermatological Treatment, 1996, 7: 223-225.

Chemical Properties

StorageStore at -20°C
M.Wt480.90
Cas No.64-75-5
FormulaC22H25ClN2O8
Solubility≥12.02 mg/mL in DMSO with gentle warming, ≥57.7 mg/mL in H2O
Chemical Name(4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
SDFDownload SDF
Canonical SMILESCC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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