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STK393606

Catalog No.
C3039
competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH
Grouped product items
SizePriceStock Qty
1mg
$59.00
In stock
5mg
$238.00
In stock
10mg
$447.00
In stock
25mg
$1,041.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Target: NAD+-dependent type-I 15-hydroxy PGDH

IC50: 26.4 nM

Ki: 5 nM

STK393606 is a competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH, with the IC50 value of 26.4±2.4 nM, and the Ki value of 5 nM, which could cause a maximum of 100% inhibition [1].

Hydroxyprostaglandin dehydrogenase 15-(NAD), also called 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH), is a critical enzyme participated in the inactivation of prostaglandins (PGs) and related eiscosanoids. 15-hydroxy PGDH belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of substrates with NAD+ or NADP+ as acceptor. 15-hydroxy PGDH could catalyze the oxidation of primary PGs to their 15-keto metabolites [2]. Radioimmunoassay for 15-hydroxy prostaglandin dehydrogenase had identified two types of enzyme activity, of which type-I used NAD+ as a cofactor, while type-II used NADP+ as a cofactor and bear wider substrate specificity [3].

In Vitro: no data available.

In Vivo: no data available.

Clinical trial: no data available.

References:
[1] Niesen F H, Schultz L, Jadhav A, et al.  High-Affinity Inhibitors of Human NAD + -Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships[J]. PLOS ONE, 2010, 5(11).
[2] Tai H, Ensor C M, Tong M, et al.  Prostaglandin catabolizing enzymes.[J]. Prostaglandins & Other Lipid Mediators, 2002: 483-493.
[3] Lee S C, Levine L.  Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.[J]. Journal of Biological Chemistry, 1975, 250(2): 548-552.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt345.2
Cas No.355827-05-3
FormulaC14H9BrN4S
Solubility≤12mg/ml in DMSO;14mg/ml in dimethyl formamide
Chemical Name2-[[(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)thio]methyl]-benzonitrile
SDFDownload SDF
Canonical SMILESBrC1=CNC2=NC(SCC3=CC=CC=C3C#N)=NC2=C1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

STK393606