Sodium Nitroprusside

mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail

Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.

Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody

Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay

SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.

Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Sodium Nitroprusside is a potent nitric oxide (NO) donor.
NO is an important cellular signaling molecule and a powerful vasodilator in the blood, thus resulting in vasodilation and increasing blood flow.
Sodium nitroprusside is a potent nitric oxide (NO) donor by releasing NO into blood. Sodium nitroprusside inhibited the contractile response of Ca2+-depleted depolarized rat aorta to extra-cellular Ca2+ and Ca2+ uptake induced by K+. Also, sodium nitroprusside decreased the rapid contraction phase induced by noradrenaline [1]. In isolated bull veins, sodium nitroprusside relaxed bull veins contraction induced by noradrenaline in a dose-dependent way [2]. In platelet-rich plasmas (PRP), sodium nitroprusside significantly inhibited platelets aggregation and also inhibited ADP and ATP release from platelets induced by collagen, which might be due to contraction of platelet smooth muscle-like protein [3].
In patients with total hip replacement under anesthesia, sodium nitroprusside (100 μg/ml) induced hypotension and reduced surgical blood loss [4].
References:
[1]. Kreye VA, Baron GD, Lüth JB, et al. Mode of action of sodium nitroprusside on vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol, 1975, 288(4): 381-402.
[2]. Gmeiner R, Riedl J, Baumgartner H. Effect of sodium nitroprusside on myocardial performance and venous tone. Eur J Pharmacol, 1975, 31(2): 287-291.
[3]. Saxon A, Kattlove HE. Platelet inhibition by sodium nitroprusside, a smooth muscle inhibitor. Blood, 1976, 47(6): 957-961.
[4]. Lawson NW, Thompson DS, Nelson CL, et al. A dosage nomogram for sodium nitroprusside-induced hypotension under anesthesia. Anesth Analg, 1976, 55(4): 574-580.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 261.92 |
Cas No. | 14402-89-2 |
Formula | C5FeN6Na2O |
Solubility | insoluble in EtOH; ≥11.2 mg/mL in DMSO; ≥51.6 mg/mL in H2O |
Chemical Name | sodium pentacyano(nitroso)ferrate(IV) |
SDF | Download SDF |
Canonical SMILES | N#C[Fe-2](N=O)(C#N)(C#N)(C#N)C#N.[Na+].[Na+] |
Shipping Condition | Ship with blue ice, or upon other requests. |
General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
