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Related Antibodies

SNX-2112

ATP-competitve Hsp90/β inhibitor

SNX-2112

Catalog No. A4068
Size Price Stock Qty
5mg $170.00 In stock
10mg $230.00 In stock
50mg $590.00 In stock
100mg $1,020.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

SNX-2112

Biological Activity

Description SNX-2112 is an ATP-competitve inhibitor of Hsp90α and Hsp90β with Ka values of both 30 nM.
Targets Hsp90α Hsp90β        
IC50 30 nM (Ka) 30 nM (Ka)        

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Chemical Properties

Cas No. 908112-43-6 SDF Download SDF
Chemical Name 4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-hydroxycyclohexyl)amino]benzamide
Canonical SMILES CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C
Formula C23H27F3N4O3 M.Wt 464.48
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autop