DNA methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group from the methyl donor, usually S-adenosyl-L-methionine (SAM) for all known DNMTs, to the 5-position of cytosine residues in DNA. In mammals, four members of the DNMT gene family have been identified and designated, DNMT1, DNMT3A, DNMT3B and DNMT3L respectively, in which DNMT1 encodes the maintenance methyltransferase, DNMT3A/3B encode the de novo methyltransferases, and DNMT3L encodes an enzyme without any inherent enzymatic activity. Mammalian DNMTs are involved in transcriptional silencing of several sequence classes and play an important role in maintaining genome stability and genomic integrity.
- C4119 2',3',5'-triacetyl-5-AzacytidineSummary: prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
- A8191 Nanaomycin A2 CitationSummary: DNMT3B inhibitor
- A1915 Zebularine1 CitationTarget: DNA Methyltransferases|Cytidine deaminasesSummary: DNA methylation inhibitor
- A1913 RG 1083 CitationTarget: DNA MethyltransferasesSummary: DNA methyltransferase inhibitor
- A1912 LomeguatribTarget: O6-methylguanine-DNA-methyl-transferase (MGMT)Summary: MGMT inhibitor
- A1907 5-Azacytidine6 CitationTarget: DNA MethyltransferasesSummary: DNA methyltransferase inhibitor.
- A1906 Decitabine (NSC127716, 5AZA-CdR)Summary: Deoxycytidine analog and cellular diifferentiation inducer
- A4176 ThioguanineSummary: Purine antimetabolite