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Catalog No.
HDAC inhibitor,novel and cell-permeable
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SizePriceStock Qty
10mM (in 1mL DMSO)
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Evaluation Sample
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Scriptaid, identified by a high-throughput transcriptional screening, is a novel histone deacetylase (HDAC) with specific potency towards class I HDACs (50% inhibition concentration IC50 values of 0.6 μM for HDAC1 and HDAC3 and 1 μM for HDAC8). Scriptaid shares a similar chemical structure with several others hydroxamic acid-containing HDAC inhibitors (such as TSA and nullscript), which consists of a hydroxamic acid group, an aliphatic chain and an aromatic cap at the other end. Scriptaid has the potential to be used for the treatment of glioblastoma multiforme (GBM), one of the most challenging solid cancers to treat, for its ability to induce apoptosis in glioblastoma cells.


Sharma V, Koul N, Joseph C, Dixit D, Ghosh S, Sen E. HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. J Cell Mol Med. 2010;14(8):2151-2161.

Hu E, Dul E, Sung CM, Chen Z, Kirkpatrick R, Zhang GF, Johanson K, Liu R, Lago A, Hofmann G, Macarron R, de los Frailes M, Perez P, Krawiec J, Winkler J, Jaye M. Identification of novel isoform-selective inhibitors within class I histone deacetylases. J Pharmacol Exp Ther. 2003;307(2):720-728.

Su GH, Sohn TA, Ryu B, Kern SE. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 2000; 60(12):3137-3142.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.287383-59-9
Solubility≥13.1 mg/mL in DMSO, ≥3.17 mg/mL in EtOH with ultrasonic and warming, <2.18 mg/mL in H2O
Chemical Name6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
SDFDownload SDF
Canonical SMILESC1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.


Cell experiment [1]:

Cell lines

MDA-MB-231 cell lines

Preparation method

The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.

Reaction Conditions

48 h; 1.0 mg/mL


Based on MTT assay a concentration of 1mg/ml of Scriptaid was chosen for the experiments in MDA-MB-231. MDA-MB-231 cells were treated with 0.1, 0.5, and 1.0 mg/mL of Scriptaid for 48 h. A dose-dependent increase in α-ER mRNA was detectable with concentrations as low as 0.1mg/ml in MDA-MB-231. Maximal α-ER mRNA was detected at 1.0mg/ml.

Animal experiment [2]:

Animal models

B6D2F1 male and female mice; SCNT embryos

Dosage form

250 nM; immersion


Treating SCNT embryos with HDAC inhibitor, scriptaid, all the important inbred mouse strains can be cloned, such as C57BL/6, C3H/He, DBA/2, and 129/Sv. Normal development, reproductive ability, and genotype in cloned inbred mice produced by scriptaid treatment. Scriptaid has also lower toxicity for embryo development that treatment of ICSI-fertilized embryos with 250 nM scriptaid, for up to 48 h, did not inhibit in vitro or in vivo development.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.


[1] Giacinti L, Giacinti C, Gabellini C, et al. Scriptaid effects on breast cancer cell lines[J]. Journal of cellular physiology, 2012, 227(10): 3426-3433.

[2] Van Thuan N, Bui H T, Kim J H, et al. The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice[J]. Reproduction, 2009, 138(2): 309-317.

Biological Activity

Description Scriptaid is an inhibitor of HDAC.
Targets HDAC          

Quality Control

Chemical structure


Related Biological Data


Related Biological Data


Related Biological Data


Research Update

1. The histone deacetylase inhibitor Scriptaid improves in vitro developmental competence of ovine somatic cell nuclear transferred embryos. Theriogenology. 2014 Jan 15;81(2):332-9. doi: 10.1016/j.theriogenology.2013.09.032. Epub 2013 Oct 6.
Scriotaid, a HDAC inhibitor, exhibited greater efficacy to ehance in vitro developmental competence in ovine SCNT embryos, where increased acetylation at acH4K12 and acH3K9 was observed at different stages.
2. Zebularine and scriptaid significantly improve epigenetic reprogramming of yak fibroblasts and cloning efficiency. Cell Reprogram. 2013 Aug;15(4):293-300. doi: 10.1089/cell.2012.0092. Epub 2013 Jun 22.
The treatment of Scriptaid significantly improved the developmental competence and cryosurvival of cloned yak embryos, whose donor nucleus was from yak fibroblasts pretreated with Scriptaid plus Zebularine.
3. Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT. Neurotherapeutics. 2013 Jan;10(1):124-42. doi: 10.1007/s13311-012-0157-2.
Scriptaid, a HDAC inhibitor, exerted long-lasting protection of motor and cognitive functions against CCI-induce injury through increasing surviving neurons and their activities in the CA3 region of the hippocampus and the pericontusional cortex, where the mechanism of protective effects includes Scriptaid-modulated AKT signaling pathway.
4. Effects of combined treatment of MG132 and scriptaid on early and term development of porcine somatic cell nuclear transfer embryos. Cell Reprogram. 2012 Oct;14(5):385-9. doi: 10.1089/cell.2012.0018. Epub 2012 Aug 23.
Although Scriptaid, a HDAC inhibitor, enhances blastocyst formation and cloning efficiency of reconstructed embryos undergone SCNT, the combination of Scriptaid and MG132 failed to show improved activities.
5. Scriptaid effects on breast cancer cell lines. J Cell Physiol. 2012 Oct;227(10):3426-33. doi: 10.1002/jcp.24043.
Scriptaid, a HDAC inhibitor, induced growth inhibition and apoptosis in human breast cancer cell lines through promoting expression of α-ER and sensitized tamoxifen hormone-resistant breast cancer cell lines to the treatment of tamoxifen.