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Riociguat

Catalog No.
A3767
Soluble guanylate cyclase (sGC) stimulator
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$90.00
In stock
5mg
$70.00
In stock
10mg
$105.00
In stock
50mg
$315.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Riociguat (BAY 63-2521; BAY 632521) is a novel drug that is currently in clinical development by Bayer. Riociguat (BAY 63-2521; BAY 632521) is a stimulator of soluble guanylate cyclase (sGC). At the moment Phase III clinical trials investigate the use of riociguat as a new approach to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of a novel class of sGC stimulators.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt422.42
Cas No.625115-55-1
FormulaC20H19FN8O2
SynonymsBAY 63-2521; BAY 632521
Solubilityinsoluble in EtOH; insoluble in H2O; ≥16.95 mg/mL in DMSO
Chemical Namemethyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-N-methylcarbamate
SDFDownload SDF
Canonical SMILESCN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control