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EGFR

EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.

Research Area

  1. Cat.No. Product Name Information
  2. B1104 AZD-9291 AZD-9291 is an irreversible inhibitor of mutant EGFR kinase with IC50 values of 15nM, 17nM and 480nM, respectively for L858R/T790M, ex19del and wild-type EGFR .
  3. A8375 AZD8931 (Sapitinib) IC50: AZD8931 showed equipotent, reversible inhibition of EGFR (IC50, 4 nmol/L), erbB2 (IC50, 3 nmol/L), and erbB3 (IC50, 4 nmol/L) phosphorylation in cells The erbB receptor family is composed of four related receptor tyrosine kinases [epidermal growth factor receptor (EGFR, erbB1), erbB2 (human epidermal growth factor receptor 2, HER2), erbB3 (HER3), and erbB4 (HER4)].
  4. A8365 Varlitinib (ARRY334543) Varlitinib is an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity.
  5. A8357 AG-1478 AG-1478 is an inhibitor of EGFR which acts on EGF-stimulated Erk1/2 phosphorylation with IC50 value of 10 uM using ovarian cell line Ishikawa .
  6. A2024 PD168393 PD168393 is an irreversible kinase inhibitor of epidermal growth factor receptor (EGFR) with IC50 value of 0.70±0.09 nM and continued to have suppressed kinase activity after 8 hr in compound-free medium.
  7. A8218 Lapatinib Lapatinib (also known as GW572016), a member of the 4-anilinoquinazoline class of kinase inhibitors, is a potent, reversible and selective small-molecule inhibitor of both epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases that inhibits recombinant EGFR and HER-2 tyrosine kinases in cell-free biochemical kinase assays with values of 50% inhibition concentration IC50 of 10.8 nmol/L and 9.3 nmol/L respectively.
  8. A3513 Ixabepilone Ixabepilone
  9. A3398 Erlotinib mesylate Erlotinib mesylate is an oral selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase withIC50 value of 20 nM.
  10. A3240 BIBX 1382 BIBX1382 is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with IC50 value of 3 nM.
  11. A8199 PD153035 hydrochloride PD153035 hydrochloride, 4-[(3-Bromopheny)amino]-6,7-dimeth oxyquinazoline hydrochloride, is a potent inhibitor of tyrosine kinase of the epidermal growth factor (EGF) receptor as well as the human epidermal growth factor receptor 2 (HER2/neu) but to a lesser degree.

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