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Wnt/β-catenin

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  1. Cat.No. Product Name Information
  2. B2306 IWR-1-endo

    IWR-1-endo is a small molecule inhibitor of Wnt Response with IC50 value of 180nM .

  3. B2305 IWP-L6 IWP-L6 is an inhibitor of Porcupine with IC50 value of 0.5nM .
  4. A8685 Wnt-C59

    Wnt-C59 is a selective inhibitor of Wnt signaling with IC50 value of 74 pM [1].

  5. A8601 Tankyrase Inhibitors (TNKS) 49 Tankyrase Inhibitors (TNKS) 49 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1nM .
  6. A8600 Tankyrase Inhibitors (TNKS) 22 Tankyrase Inhibitors (TNKS) 22 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1nM .
  7. A8396 CHIR-99021 (CT99021) HCl CHIR-99021 is a highly specific glycogen synthase kinase-3 (GSK-3) inhibitor which can inhibit both isoforms with IC50 of 10 nM (GSK-3α) and 6.7 nM (GSK-3β).
  8. A1877 XAV-939 XAV-939 is a small-molecule inhibitor of tankyrase 1/2 with IC50 values of 4 and 11 nM, respectively .
  9. A8217 ICG 001

    ICG001 is a small molecule inhibitor that targets Wnt/β-catenin pathway. It inhibits TCF/β-catenin mediated transcription by competing with β-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 µM . It can be used to specifically evaluate the role of CBP/beta-catenin association on WNT signaling and cell physiology.

  10. A8213 KY 02111 KY 02111 is a selective inhibitor of Wnt may by targeting the downstream from GSK3βand APC in β-catenin destruction complex [1].
  11. A4529 JW 55 Increased nuclear accumulation of β-catenin, a mediator of canonical Wnt signaling, is found in numerous tumors and is frequently associated with tumor progression and metastasis.

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