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DPP-4

Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.

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  1. Cat.No. Product Name Information
  2. A4038 Alogliptin (SYR-322) DPP-4 inhibitor,potent and highly selective
  3. A3156 Alogliptin Benzoate DPP-4 inhibitor,selective and potent,antidiabetic drug
  4. A4425 DPPI 1c hydrochloride DPP-IV Inhibitor
  5. A4033 Glimepiride Sulfonylurea compound
  6. A4426 K 579 Dipeptidyl peptidase IV inhibitor
  7. A4034 Linagliptin (BI-1356) DDP-4 inhibitor,highly potent and competitive
  8. B5868 MK3102 Novel long-acting DPP-4 inhibitor
  9. A4427 NVP DPP 728 dihydrochloride DPP-IV inhibitor
  10. C3136 P32/98 (hemifumarate) competitive transition-state substrate analog inhibitor of DPP IV
  11. A4428 PK 44 phosphate DPP-IV inhibitor

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