IRAK inhibitor 4
IRAK inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase [1].
IRAK-4 belongs to Interleukin-1 Receptor-Associated Kinase, which are key components in the signal transduction pathways. IRAK-4 is an essential signal transducer downstream of interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R) and Toll-like receptors (TLRs). Inhibition of IRAK-4 can modulate its function, thus toning down inflammatory responses. IRAK inhibitor 4 is an indazole inhibitor. As inhibitors of IRAK-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders [1].
References:
[1] Zhulun Wang, Holger Wesche, Tracey Stevens, Nigel Walker and Wen-Chen Yeh. IRAK-4 Inhibitors for Inflammation. Current Topics in Medicinal Chemistry. 2009, 9: 724-737.
| Storage | Store at -20°C |
| M.Wt | 620.66 |
| Cas No. | 1012104-68-5 |
| Formula | C33H35F3N6O3 |
| Solubility | Soluble in DMSO |
| Chemical Name | 1-(4-hydroxycyclohexyl)-N-(3-methylbutyl)-2-[[5-[2-(trifluoromethoxy)phenyl]-1H-indazol-3-yl]amino]benzimidazole-5-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | CC(C)CCNC(=O)C1=CC2=C(C=C1)N(C(=N2)NC3=NNC4=C3C=C(C=C4)C5=CC=CC=C5OC(F)(F)F)C6CCC(CC6)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | IRAK inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase. | |||||
| Targets | IRAK | |||||
| IC50 | ||||||
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
