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Cathepsin

Cathepsins (the term standing for “lysosomal proteolytic enzyme”) are a class of globular proteases that catalyze the hydrolysis of intracellular peptides and also exhibit extracellular functions. So far, a total of sixteen members of human cathepsin family have been identified, which are divided into three subfamilies, including cysteine protease family (cathepsin B, C, F, H, L, K, O, S, V, W, X and Z), serine carboxypeptidase family (cathepsin A and G) and aspartic protease family (cathepsin D and E). Cathepsins are highly expressed in various human cancers with each member playing different roles in distinct tumorigenic processes, including proliferation, angiogenesis, metastasis and invasion.

Antibodies

Cat.No. Product Name Information
T1053 Cathepsin D Antibody Polyclonal Cathepsin D antibody, reacts with preprocathepsin D, procathepsin D and the heavy chain subunit of mature cathepsin D
T1051 Cathepsin B Antibody (h) Polyclonal Cathepsin B antibody, reacts with total human cathepsin B protein
T1052 Cathepsin B Antibody (m) Polyclonal Cathepsin B antibody, reacts with total cathepsin B protein

Biochemicals

Cat.No. Product Name Information
A2576 E-64 _{Top Seller} Irriversible cysteine protease inhibitor
A8162 E-64-c E-64-c is an effective synthetic calpain inhibitor composed from E-64, which also inhibits cathepsin B, cathepsin H, and cathepsin L (cysteine proteases).
A1903 E 64d _{Top Seller} Cell-permeable, irreversible cysteine protease inhibitor
A1926 CA 074 _{Top Seller} Cathepsin B inhibitor
A8239 CA-074 Me A cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
A8174 Cathepsin G Inhibitor I _{Top Seller} Competitive and reversible non peptide inhibitor of cathepsin G
A3284 Cathepsin S inhibitor A slow, tight-binding reversible inhibitor of recombinant cathepsin S (Ki = 185 pM). Exhibits about 410-fold greater selectivity for cathepsin S compared to cathepsin B (Ki = 76 nM).
A2487 Odanacatib (MK-0822) inhibitor of cathepsin K
A4422 L 006235 Potent, reversible cathepsin K inhibitor (IC₅₀ = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence.
A4412 MDL 28170 Potent, selective inhibitor of calpain and cathepsin B (K_i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.
A4424 SID 26681509 Potent and reversible human cathepsin L inhibitor