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Cathepsin

Cathepsins (the term standing for “lysosomal proteolytic enzyme”) are a class of globular proteases that catalyze the hydrolysis of intracellular peptides and also exhibit extracellular functions. So far, a total of sixteen members of human cathepsin family have been identified, which are divided into three subfamilies, including cysteine protease family (cathepsin B, C, F, H, L, K, O, S, V, W, X and Z), serine carboxypeptidase family (cathepsin A and G) and aspartic protease family (cathepsin D and E). Cathepsins are highly expressed in various human cancers with each member playing different roles in distinct tumorigenic processes, including proliferation, angiogenesis, metastasis and invasion.

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Antibodies

  1. Cat.No. Product Name Information
  2. T1053 Cathepsin D Antibody Polyclonal Cathepsin D antibody, reacts with preprocathepsin D, procathepsin D and the heavy chain subunit of mature cathepsin D
  3. T1051 Cathepsin B Antibody (h) Polyclonal Cathepsin B antibody, reacts with total human cathepsin B protein
  4. T1052 Cathepsin B Antibody (m) Polyclonal Cathepsin B antibody, reacts with total cathepsin B protein

Biochemicals

  1. Cat.No. Product Name Information
  2. A2576 E-64 Top Seller Cysteine protease inhibitor,irriversible
  3. B2084 Cathepsin Inhibitor 1 Cathepsin inhibitor
  4. A8162 E-64-c Inhibitor of cysteine proteinases
  5. A1903 E 64d Top Seller Cysteine protease inhibitor
  6. A1926 CA 074 Top Seller Cathepsin B inhibitor
  7. A8239 CA-074 Me Cathepsin B inhibitor
  8. A3284 Cathepsin S inhibitor Blocks MHCII antigen presentation
  9. A8174 Cathepsin G Inhibitor I Top Seller Cathepsin G inhibitor
  10. A2487 Odanacatib (MK-0822) Cathepsin K,potent and selective
  11. A4422 L 006235 Cathepsin K inhibitor
  12. A4412 MDL 28170 Calpain and cathepsin B inhibitor, selective
  13. A4424 SID 26681509 Human cathepsin L inhibitor,potent and reversible