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Aurora Kinase

Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.

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Biochemicals

  1. Cat.No. Product Name Information
  2. A4111 VX-680 (MK-0457,Tozasertib) Top Seller Aurora kinase inhibitor
  3. A4122 PHA-680632 Aurora kinase inhibitor,novel and potent
  4. A4124 TAK-901 Novel Aurora A/B inhibitor
  5. A4125 CYC116 Potent Aurora A/B inhibitor
  6. A4127 GSK1070916 Aurora B/C inhibitor
  7. A4128 PF-03814735 Aurora A/B inhibitor
  8. A3214 AZD1152 Aurora B kinase inhibitor,highly potent and selective
  9. A3760 Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor
  10. A3804 SCH-1473759 Aurora A/B inhibitor
  11. A3939 XL228 IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor
  12. A4488 Anacardic acid HAT inhibitor
  13. A4489 TC-A 2317 hydrochloride Aurora kinase A inhibitor,potent and selective
  14. A4121 SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective
  15. A4120 MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective
  16. A4119 AMG-900 Aurora kinase inhibitor
  17. A4112 Barasertib (AZD1152-HQPA) Top Seller Aurora Kinase B inhibitor, Potent and selective
  18. A4113 ZM 447439 Aurora Kinase inhibitor,potent and selective
  19. A4129 ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor
  20. A4130 ENMD-2076 Selective Aurora A/Flt3 inhibitor
  21. A4131 CCT129202 Aurora kinase inhibitor,ATP-competitive and potent
  22. A4132 CCT137690 Aurora A/B/C inhibitor
  23. A4114 MLN8054 Aurora A inhibitor
  24. A4115 JNJ-7706621 Potent CDK/Aurora kinase inhibitor
  25. A4116 Danusertib (PHA-739358) Top Seller Pan-aurora kinase inhibitor
  26. A4117 AT9283 Aurora kinase/JAK inhibitor
  27. A4118 Hesperadin Top Seller Aurora B kinase inhibitor
  28. A4110 MLN8237 (Alisertib) Top Seller Aurora A Kinase inhibitor, Potent and selective
  29. A4126 Aurora A Inhibitor I Aurora A inhibitor
  30. A8807 MK-8745 Aurora A inhibitor,potent and selective