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Raloxifene HCl

Catalog No.
B1515
Estrogen receptor (ER)
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$55.00
In stock
50mg
$50.00
In stock
100mg
$80.00
In stock

Background

Raloxifene HCl(LY139481)is a potent and selective of estrogen receptor (ER) with the IC50 value of 2.9~5.7nM [1].

Raloxifene HCl(LY139481)is a selective and uncompetitive of estrogen receptor (ER) with the IC50 value of 2.9~5.7nM for phthalazine oxidase in human liver cytosol. In addition, Raloxifene has been found to be a potent inhibitor for the three oxidation reactions with the Ki values of 0.87nM, 1.2nM and 1.4nM for phthalazine oxidation, vanillin oxidation and nicotine-△1’(5‘)-iminium ion oxidation, respectively. And the inhibition of Raloxifene HCl is not time-dependent fashion. Apart from these, Raloxifene HCl has been reported to noncompetitively inhibit the aldehyde oxidase-catalyzed reduction reaction with the Ki value of 52nM [1].

References:
[1] Obach RS.Potent inhibition of human liver aldehyde oxidase by raloxifene.

Drug Metab Dispos. 2004 Jan;32(1):89-97.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt510.04
Cas No.82640-04-8
FormulaC28H28ClNO4S
Solubility≥22.35mg/mL in DMSO
Chemical Name[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone;hydrochloride
SDFDownload SDF
Canonical SMILESC1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Chemical structure

Raloxifene HCl