Probucol

mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail

Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.

Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody

Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay

SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.

Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Probucol is a lipid-lowering agent with anti-inflammatory and antioxidant properties [1-3].
Probucol inhibits the oxidation of cholesterol in low-density lipoprotein, preventing the formation of macrophage-derived foam cells which lead to atherosclerotic vascular lesions. However, the application of probucol is limited, because it leads to the reduction of high-density lipoprotein cholesterol as well [1].
In J774 macrophages, probucol at 10 μmol/L inhibited cholesterol efflux up to 80% by impairing the translocation of ATP-binding cassette transporter A1 (ABCA1) from intracellular compartments to the plasma membrane. Probucol also suppressed the formation of an ABCA1-linked cholesterol oxidase sensitive plasma membrane domain [2].
In a mouse model of Huntington’s disease, long-term probucol treatment (3.5 mg/kg/day, p.o., for 2 months) protected against behavioral and striatal biochemical changes induced by 3-nitropropionic acid (3-NP), attenuating 3-NP-induced motor impairments and striatal oxidative stress, without rescuing complex II inhibition. Furthermore, probucol was able to increase activity of glutathione peroxidase, an enzyme involved in mediating the detoxification of peroxides in the central nervous system [3].
References:
[1]. Yamamoto A. A uniqe antilipidemic drug--probucol. Journal of Atherosclerosis and Thrombosis, 2008, 15(6): 304-305.
[2]. Favari E, Zanotti I, Zimetti F, et al. Probucol inhibits ABCA1-mediated cellular lipid efflux. Arteriosclerosis, Thrombosis, and Vascular Biology, 2004, 24(12): 2345-2350.
[3]. Colle D, Santos D B, Moreira E L, et al. Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats. PLoS One, 2013, 8(6): e67658.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 516.84 |
Cas No. | 23288-49-5 |
Formula | C31H48O2S2 |
Solubility | insoluble in H2O; ≥17.45 mg/mL in DMSO; ≥64.2 mg/mL in EtOH |
Chemical Name | 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol |
SDF | Download SDF |
Canonical SMILES | CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C |
Shipping Condition | Ship with blue ice, or upon other requests. |
General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. |
Quality Control & MSDS
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Chemical structure
