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PluriSIn #1 (NSC 14613)

Catalog No.
SCD1 inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
In stock
Evaluation Sample
In stock
In stock
In stock

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Email: [email protected]

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NSC 14613 is a pluripotent cell-specific inhibitor (PluriSIn) that selectively eliminates human pluripotent stem cells (hPSCs) leaving a large array of progenitor and differentiated cells unaffected. Among 15 identified PluriSIns, NSC 14613 (also known as PluriSIn #1) is a derivative of N-acyl phenylhydrazine that shares a common structure moiety, phenylhydrazine (Ph-N[H,C]-NH) with 9 other PluriSIns. NSC 14613 is also an inhibitor of stearoyl-coA desaturase (SCD1) that inhibits the activity of SCD1 in hPSCs causing the imbalance between substrates and products and subsequently resulting in the accumulation of palmitate and stearate and the deprivation of oleate. Study results have suggested that NSC 14613 is able to induce ER stress, protein synthesis attenuation and apoptosis in hPSCs and can be used to prevent teratoma formation from tumorigenic undifferentiated cells.


Ben-David U, Gan QF, Golan-Lev T, Arora P, Yanuka O, Oren YS, Leikin-Frenkel A, Graf M, Garippa R, Boehringer M, Gromo G, Benvenisty N. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell. 2013 Feb 7;12(2):167-79

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.91396-88-2
Solubilityinsoluble in H2O; ≥15.67 mg/mL in EtOH with gentle warming and ultrasonic; ≥6.75 mg/mL in DMSO
Chemical NameN'-phenylpyridine-4-carbohydrazide
SDFDownload SDF
Canonical SMILESC1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Biological Activity

Description PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1).
Targets Dehydrogenase          

Quality Control

Chemical structure

PluriSIn #1 (NSC 14613)

Related Biological Data

PluriSIn #1 (NSC 14613)

Related Biological Data

PluriSIn #1 (NSC 14613)