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PluriSIn #1 (NSC 14613)

In stock
Catalog No.
A4351
SCD1 inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$65.00
In stock
Evaluation Sample
$28.00
In stock
10mg
$68.00
In stock
50mg
$189.00
In stock

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Background

NSC 14613 is a pluripotent cell-specific inhibitor (PluriSIn) that selectively eliminates human pluripotent stem cells (hPSCs) leaving a large array of progenitor and differentiated cells unaffected. Among 15 identified PluriSIns, NSC 14613 (also known as PluriSIn #1) is a derivative of N-acyl phenylhydrazine that shares a common structure moiety, phenylhydrazine (Ph-N[H,C]-NH) with 9 other PluriSIns. NSC 14613 is also an inhibitor of stearoyl-coA desaturase (SCD1) that inhibits the activity of SCD1 in hPSCs causing the imbalance between substrates and products and subsequently resulting in the accumulation of palmitate and stearate and the deprivation of oleate. Study results have suggested that NSC 14613 is able to induce ER stress, protein synthesis attenuation and apoptosis in hPSCs and can be used to prevent teratoma formation from tumorigenic undifferentiated cells.

Reference

Ben-David U, Gan QF, Golan-Lev T, Arora P, Yanuka O, Oren YS, Leikin-Frenkel A, Graf M, Garippa R, Boehringer M, Gromo G, Benvenisty N. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell. 2013 Feb 7;12(2):167-79

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt213.24
Cas No.91396-88-2
FormulaC12H11N3O
Solubility≥6.75 mg/mL in DMSO, ≥15.67 mg/mL in EtOH with ultrasonic and warming, <2.48 mg/mL in H2O
Chemical NameN'-phenylpyridine-4-carbohydrazide
SDFDownload SDF
Canonical SMILESC1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1).
Targets Dehydrogenase          
IC50            

Quality Control

Chemical structure

PluriSIn #1 (NSC 14613)

Related Biological Data

PluriSIn #1 (NSC 14613)

Related Biological Data

PluriSIn #1 (NSC 14613)