Piericidin A
Piericidin A (CAS 2738-64-9) is a mitochondrial respiratory chain inhibitor, primarily targeting complex I (NADH:ubiquinone oxidoreductase). Acting at low concentrations, piericidin A interferes specifically with electron transfer near NADH dehydrogenase. At higher concentrations, it also impairs succinate dehydrogenase activity, partially reversible by coenzyme Q. In animal models, its administration causes increased respiratory rate and decreased blood pressure, effects partially antagonized by vitamin K3. Currently, piericidin A serves as a valuable research tool for studying mitochondrial function and energy metabolism.
- 1. Lucia Del Prado, Myriam Jaraíz-Rodríguez, et al. "Compensatory activity of the PC-ME1 metabolic axis underlies differential sensitivity to mitochondrial complex I inhibition." Nat Commun. 2024 Oct 7;15(1):8682. PMID: 39375345
- 2. Xingchen Guo, Sheng Chen, et al. "AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation." FEBS Lett. 2021 Oct;595(19):2447-2462. PMID: 34387860
| Physical Appearance | A solution in ethanol |
| Storage | Store at -80°C |
| M.Wt | 415.6 |
| Cas No. | 2738-64-9 |
| Formula | C25H37NO4 |
| Synonyms | AR 054|Shaoguanmycin B|SN 198E |
| Solubility | Soluble in DMSO |
| Chemical Name | 2-[(2E,5E,7E,11E)-10R-hydroxy-3,7,9R,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol |
| SDF | Download SDF |
| Canonical SMILES | COC1=C(O)C(C)=C(C/C=C(C)/C/C=C/C(C)=C/[C@H]([C@@H](O)/C(C)=C/C)C)N=C1OC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
Lepidopteran Tn5B1-4 cells, as well as human HepG2 and Hek293 cells |
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Reaction Conditions |
0.02, 0.04, 0.08, 0.16 and 0.32 μM piericidin A for Tn5B1-4 cells; 180, 210, 240, 270 and 300 μM for HepG2 and Hek293 cells; for 48 h incubation |
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Applications |
Piericidin A inhibited the viability of Tn5B1-4 cells in a time- and concentration-dependent manner with an IC50 value of 0.061 μM, whilst piericidin A showed slight inhibitory effect on the viability of HepG2 and Hek293 cells with IC50 values of 233.97 μM and 228.96 μM, respectively. Piericidin A-induced apoptosis of Tn5B1-4 cells coincided with a decrease in the mitochondrial membrane potential. |
| Animal experiment:[2] | |
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Animal models |
Male rats weighing 300 to 370 g |
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Dosage form |
0.167 mg/kg Administered through femoral vein |
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Applications |
Piericidin A at the dose of 0.167 mg/kg substantially increased the respiratory rate and rapidly lowered the blood pressure in rats, which could be reversed by vitamin K3 (10 ~ 40 mg/kg). |
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Note |
The technical data provided above is for reference only. |
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References: 1. Muhayimana S, Zhang X, Xu J, et al. Cytotoxic selectivity and apoptosis induction of piericidin A contributes potentially to its insecticidal effect against Mythimna separata (Lepidoptera: Noctuidae) larvae. Pesticide Biochemistry and Physiology, 2019, 157: 19-25. 2. Mitsui T, Fukami J, Fukunaga K, et al. Studies on piericidin antagonistic effect of vitamin K3 on the respiratory chain of insects and mammals in the presence of piericidin A. Agricultural and Biological Chemistry, 1970, 34(7): 1101-1109. |
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Quality Control & MSDS
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Chemical structure
