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Pentamidine

Catalog No.
A8498
Drug to treat protozoal diseases
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
50mg
$52.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

Used as a drug to treat protozoal diseases, such as amoebic dysentery, malaria and trypanosomiasis. Also has been shown to be effective for both prophylaxis of pneumocystic carinii pneumonia (PCC).

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt340.42
Cas No.100-33-4
FormulaC19H24N4O2
Solubility≥13.5mg/mL in DMSO
Chemical Name4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
SDFDownload SDF
Canonical SMILESC1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Protocol

Cell experiment [1]:

Cell lines

Melanoma (WM9), prostate carcinoma (DU145 and C4–2), ovarian carcinoma (Hey), colon carcinoma (WM480), and lung carcinoma (A549)

Preparation method

The solubility of this compound in DMSO is ≥13.5mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

10 μg/ml

Applications

The growth of all six of the cell lines in culture was inhibited by pentamidine in a concentration-dependent manner with complete growth inhibition of the cell lines occurring at 10 μg/ml. These results demonstrated an in vitro growth-inhibitory activity of pentamidine against different human cancer cell lines that expressed the endogenous PRL phosphatases.

Animal experiment [1]:

Animal models

Athymic nude mouse model

Dosage form

6–10 mg/kg (i.m.), once every two days

Application

At the 16th week of the study, the tumor size of the experimental mice treated with Pentamidine was similar to that at the beginning of the treatment, while the tumors of the control mice grew so fast that humanitarian sacrifices were required at 4 weeks. At the end of the study period, there were no significant histological changes in the internal organs (heart, kidney, liver, lung, and spleen) of Pentamidine-treated mice. The tumors of these mice were evaluated and found that necrosis accounted for more than 50% of the total tumors, while the tumors of untreated control mice did not.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Pathak MK, Dhawan D, Lindner DJ, Borden EC, Farver C, Yi T. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. PubMed PMID: 12516958.

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