PD-1/PD-L1 Inhibitor 3
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
PD-1/PD-L1 Inhibitor 3 is a PD-1/PD-L1 interaction inhibitor.
The anti-PD-1 and anti-PD-L1 compounds have been found to show impressive antitumor effects in various malignancies, such as melanoma. The greatest clinical outcome in unselected patients has been observed in melanoma. The tumor expression of PD-L1 is suggested to be a suggestive, inadequate, and predictive of response to immune-checkpoint blockade.
In vitro: PD-1/PD-L1 inhibitor 3 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (PD-1) with its ligand protein (PD-L1) and with CD80. PD-1/PD-L1 inhibitor 3 was also found to act as an immunomodulator. In addition, PD-1/PD-L1 Inhibitor 3 was found to have highly efficacious binding to PD-L1 and promote the increased functional activities of T cells. Therefore, PD-1/PD-L1 inhibitor 3 could be regarded as a promising therapeutic treatment of cancer and infectious diseases, such as hepatitis C .
In vivo: So far, there is no animal in vivo study reported for PD-1/PD-L1 Inhibitor 3.
Clinical trial: Up to now, PD-1/PD-L1 Inhibitor 3 is still in the preclinical development stage.
 MILLER Michael Matthew, et al. Patent, Pub. No.:WO/2014/151634
|Storage||Store at -20°C|
|Solubility||Soluble in DMSO|
|Canonical SMILES||O=C(NCC(N)=O)[[email protected]]1NC([[email protected]@H](NC([[email protected]@H](N(C)C([[email protected]](CCCC)N(C)C([[email protected]](CC2=CNC3=C2C=CC=C3)NC([[email protected]](CO)NC([[email protected]](CC4=CNC5=C4C=CC=C5)NC(CN(C)C([[email protected]](CC(C)C)NC([[email protected]@H](NC([[email protected]]6N(C([[email protected]](CC(N)=O)NC([[email protected]@H](N(C(C(NC(CSC1)=O)CC7=CC=CC=C7)=O)C)C)=O)=O)CCC6)=O)CC8=CN=|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|