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PD-1/PD-L1 Inhibitor 3

Catalog No.
B6191
PD-1/PD-L1 interaction inhibitor
Grouped product items
SizePriceStock Qty
1mg
$282.00
Ship with 5-10 days
5mg
$997.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

PD-1/PD-L1 Inhibitor 3 is a PD-1/PD-L1 interaction inhibitor.

The anti-PD-1 and anti-PD-L1 compounds have been found to show impressive antitumor effects in various malignancies, such as melanoma. The greatest clinical outcome in unselected patients has been observed in melanoma. The tumor expression of PD-L1 is suggested to be a suggestive, inadequate, and predictive of response to immune-checkpoint blockade.

In vitro: PD-1/PD-L1 inhibitor 3 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (PD-1) with its ligand protein (PD-L1) and with CD80. PD-1/PD-L1 inhibitor 3 was also found to act as an immunomodulator. In addition, PD-1/PD-L1 Inhibitor 3 was found to have highly efficacious binding to PD-L1 and promote the increased functional activities of T cells. Therefore, PD-1/PD-L1 inhibitor 3 could be regarded as a promising therapeutic treatment of cancer and infectious diseases, such as hepatitis C [1].

In vivo: So far, there is no animal in vivo study reported for PD-1/PD-L1 Inhibitor 3.

Clinical trial: Up to now, PD-1/PD-L1 Inhibitor 3 is still in the preclinical development stage.

References:
[1] MILLER Michael Matthew, et al.  Patent, Pub. No.:WO/2014/151634

Chemical Properties

StorageStore at -20°C
M.Wt1852.17
Cas No.1629654-95-0
FormulaC89H126N24O18S
SolubilitySoluble in DMSO
Chemical Name(3S,6S,12S,15S,18S,21S,24S,27S,30R,39S,42S,47aS)-3-((1H-imidazol-5-yl)methyl)-12,18-bis((1H-indol-3-yl)methyl)-N,42-bis(2-amino-2-oxoethyl)-36-benzyl-21,24-dibutyl-27-(3-guanidinopropyl)-15-(hydroxymethyl)-6-isobutyl-8,20,23,38,39-pentamethyl-1,4,7,10,13,
SDFDownload SDF
Canonical SMILESO=C(NCC(N)=O)[[email protected]]1NC([[email protected]@H](NC([[email protected]@H](N(C)C([[email protected]](CCCC)N(C)C([[email protected]](CC2=CNC3=C2C=CC=C3)NC([[email protected]](CO)NC([[email protected]](CC4=CNC5=C4C=CC=C5)NC(CN(C)C([[email protected]](CC(C)C)NC([[email protected]@H](NC([[email protected]]6N(C([[email protected]](CC(N)=O)NC([[email protected]@H](N(C(C(NC(CSC1)=O)CC7=CC=CC=C7)=O)C)C)=O)=O)CCC6)=O)CC8=CN=
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

PD-1/PD-L1 Inhibitor 3