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Paxilline

Catalog No.
B6920
high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels blocker
Grouped product items
SizePriceStock Qty
5mg
$131.00
Ship with 5-10 days
10mg
$238.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

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Background

Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa, KCa1.1) channels[1,2]. It also enhances the binding of charybdotoxin, a peptidyl neurotoxin, to BKCa channels. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (IC50 = 5 - 50 μM)[3]. 

References:

[1]. Sanchez M, McManus O B. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology, 1996,  35(7): 963-968.

[2]. Li G, Cheung D W. Effects of paxilline on K+ channels in rat mesenteric arterial cells. European Journal of Pharmacology , 1999, 372: 103-107.

[3]. Knaus H G, McManus O B, Lee S H, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry, 1994, 33(19): 5819-5828.

Chemical Properties

Physical AppearanceA crystalline solid
StorageDesiccate at -20°C
M.Wt435.56
Cas No.57186-25-1
FormulaC27H33NO4
SolubilitySoluble in DMSO
Chemical Name(2R,4bS,6aR,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
SDFDownload SDF
Canonical SMILESO[[email protected]]1(C2=C3)[[email protected]@](CC[[email protected]@H]2O[[email protected]](C(C)(C)O)C3=O)(C)[[email protected]](C(NC4=CC=CC=C54)=C5C6)(C)[[email protected]@H]6CC1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Paxilline