In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa, KCa1.1) channels[1,2]. It also enhances the binding of charybdotoxin, a peptidyl neurotoxin, to BKCa channels. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (IC50 = 5 - 50 μM).
. Sanchez M, McManus O B. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology, 1996, 35(7): 963-968.
. Li G, Cheung D W. Effects of paxilline on K+ channels in rat mesenteric arterial cells. European Journal of Pharmacology , 1999, 372: 103-107.
. Knaus H G, McManus O B, Lee S H, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry, 1994, 33(19): 5819-5828.
|Physical Appearance||A crystalline solid|
|Storage||Desiccate at -20°C|
|Solubility||Soluble in DMSO|
|Canonical SMILES||O[[email protected]]1(C2=C3)[[email protected]@](CC[[email protected]@H]2O[[email protected]](C(C)(C)O)C3=O)(C)[[email protected]](C(NC4=CC=CC=C54)=C5C6)(C)[[email protected]@H]6CC1|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|