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p-Cresyl sulfateProtein-bound uremic retention solute

p-Cresyl sulfate

Catalog No. A8895
Size Price Stock Qty
10mg $350.00 In stock
300mg $3,200.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

p-Cresyl sulfate

p-Cresyl sulfate Dilution Calculator

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Chemical Properties

Cas No. 3233-58-7 SDF Download SDF
Chemical Name p-tolyl hydrogen sulfate
Canonical SMILES CC1=CC=C(OS(O)(=O)=O)C=C1
Formula C7H8O4S M.Wt 188.20
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

The p-Cresol is a protein-bound uremic retention solute 1.

Free p-Cresol was found to be a cardiovascular risk factor in non-diabetic hemodialysis patients. In patients with diabetes, the level of both free p-cresol and total p-cresol were markedly higher. In patients treated by hemodialysis, the levels of these two forms of p-cresol were also significantly higher than that of patients treated by hemodiafiltration. The univariate cox proportional hazard analysis showed that the concentration of free p-cresol was obviously associated with cardiovascular disease (CVD). Quite many patients with high free p-cresol concentrations had new fatal or non-fatal cardiovascular events. Besides that, p-cresol was also found to inhibit cell proliferation. It inhibited the proliferation of cultured endothelial cells by 26% without affecting cell viability. Moreover, p-cresol treatment reduced endothelial wound repair by 19%, 28% and 40% at concentrations of 10, 25 and 50 μg/ml, respectively 1,2.

References:
1. Meijers B K I, Bammens B, De Moor B, et al. Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Kidney international, 2008, 73(10): 1174-1180.
2. Dou L, Bertrand E, Cerini C, et al. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney international, 2004, 65(2): 442-451.