In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Oxytocin is a positive allosteric modulator of μ opioid receptor (MOR) signaling .
Oxytocin, a 9-amine neuropeptide synthesized in the paraventricular nucleus (PVN) and the supraoptic nucleus of the hypothalamus, is secreted from the posterior pituitary into the systemic circulation, playing an essential role in mammalian labor, lactation, maternal bonding, and social affiliation. Oxytocin has been reported to exert an analgesic effect as well .
In hMOR-expressing HEK293 cells, Oxytocin alone showed no direct agonistic effect on human MOR at concentration up to 10-5 M, but treatment with 10-6 M Oxytocin markedly enhanced the MOR signaling stimulated by 10-6 M endomorphin-1, β-endorphin, morphine, fentanyl, as well as DAMGO. Moreover, in the competitive receptor-binding assay, 10-6 M Oxytocin did not alter the affinity of endomorphin-1 or morphine for MOR .
Intracerebroventricular Oxytocin administration (0.2 μg) robustly increased medial nucleus accumbens shell (NAcSh) neuron mean firing rate in rats, but did not do so after rats were repeatedly treated with morphine .
. Meguro Y, Miyano K, Hirayama S, et al. Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator. Journal of Pharmacological Sciences, 2018, 137(1): 67-75.
. Moaddab M, Hyland B I, Brown C H. Oxytocin excites nucleus accumbens shell neurons in vivo. Molecular and Cellular Neuroscience, 2015, 68: 323-330.
- 1. Lin CH, Tsai CC, et al. "Oxytocin maintains lung histological and functional integrity to confer protection in heat stroke." Sci Rep. 2019 Dec 5;9(1):18390. PMID:31804535
- 2. An X, Sun X, et al. "Protective effect of oxytocin on LPS-induced acute lung injury in mice." Sci Rep. 2019 Feb 26;9(1):2836. PMID:30808956
|Storage||Store at -20°C|
|Solubility||≥182.8mg/mL in DMSO|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.|
Quality Control & MSDS
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