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ONC201

Catalog No.
A8724
activates p53-independent apoptosis
Grouped product items
SizePriceStock Qty
5mg
$58.00
In stock
10mg
$86.00
In stock
50mg
$250.00
In stock
100mg
$480.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

ONC201 (CAS: 1616632-77-9) is a small molecule that induces p53-independent apoptosis primarily through engagement of the integrated stress response (ISR) pathway. Mechanistically, ONC201 activates the transcription factor ATF4, leading to expression of pro-apoptotic genes and suppression of the mTORC1 pathway via DDIT4 induction. In hematologic malignancies such as acute myeloid leukemia (AML) and mantle cell lymphoma, ONC201 demonstrates antiproliferative and apoptotic activity, independent of common resistance factors. It also upregulates death receptor 5 (DR5) and TRAIL expression, promoting apoptosis in solid tumor models. ONC201 is employed in preclinical research examining apoptotic pathways, cancer therapy resistance mechanisms, and combination oncology regimens.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt386.49
Cas No.1616632-77-9
FormulaC24H26N4O
Solubilityinsoluble in H2O; ≥10 mg/mL in EtOH with ultrasonic; ≥16 mg/mL in DMSO
Chemical Name7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one
SDFDownload SDF
Canonical SMILESCC1=CC=CC=C1CN(C2=NCCN32)C(C(C4)=C3CCN4CC5=CC=CC=C5)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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