ONC201
ONC201 (CAS: 1616632-77-9) is a small molecule that induces p53-independent apoptosis primarily through engagement of the integrated stress response (ISR) pathway. Mechanistically, ONC201 activates the transcription factor ATF4, leading to expression of pro-apoptotic genes and suppression of the mTORC1 pathway via DDIT4 induction. In hematologic malignancies such as acute myeloid leukemia (AML) and mantle cell lymphoma, ONC201 demonstrates antiproliferative and apoptotic activity, independent of common resistance factors. It also upregulates death receptor 5 (DR5) and TRAIL expression, promoting apoptosis in solid tumor models. ONC201 is employed in preclinical research examining apoptotic pathways, cancer therapy resistance mechanisms, and combination oncology regimens.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 386.49 |
| Cas No. | 1616632-77-9 |
| Formula | C24H26N4O |
| Solubility | insoluble in H2O; ≥10 mg/mL in EtOH with ultrasonic; ≥16 mg/mL in DMSO |
| Chemical Name | 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=CC=C1CN(C2=NCCN32)C(C(C4)=C3CCN4CC5=CC=CC=C5)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
