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Naltrindole hydrochloride

Catalog No.
B6429
δ opioid antagonist
Grouped product items
SizePriceStock Qty
5mg
$164.00
In stock
10mg
$224.00
In stock
25mg
$488.00
In stock
50mg
$877.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Naltrindole hydrochloride is a cell permeable, highly selective non-peptide δ opioid antagonist (Ki = 0.02 nM). 

In U266 cells, naltrexone treatment can significantly reduce the active phosphorylated form of kinases, and extracellular signaling regulates kinase and Akt levels, which may be related to its anti-proliferative activity[1]. 

In mice, naltrindole (20 mg/kg, s.c) antagonizes the δ-selective agonist effect of enkephalin (DSLET), but does not prevent the anti-nociceptive effects of morphine or U50488H. Naltrexone is the only highly selective delta antagonist that is active when administered peripherally[2]. 

References:

[1]. Mundra J J, et al. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther, 2012, 342(2): 273-87.

[2]. Portoghese P S, et al. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. Eur J Pharmacol, 1988, 146(1): 185-6.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at RT
M.Wt450.96
Cas No.111469-81-9
FormulaC26H26N2O3·HCl
SolubilitySoluble in DMSO
Chemical Name(4bS,8R,8aR,14bR)-7-(cyclopropylmethyl)-5,6,7,8,8a,9,14,14b-octahydro-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a-diol hydrochloride
SDFDownload SDF
Canonical SMILESO[[email protected]]([[email protected]@H]1N(CC2CC2)CC3)(CC4=C5NC6=CC=CC=C46)[[email protected]@]3(C7=C(C=C8)C1)[[email protected]]5OC7=C8O.Cl
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Naltrindole hydrochloride