N6-Methyl-dATP
N6-Methyl-dATP is a methylated deoxyadenosine triphosphate, with the N6 position of its adenine ring replaced by a methyl group, and it belongs to epigenetic related nucleotide analogues. This modification can alter the spatial structure and chemical properties of nucleotides, interfering with the recognition and incorporation process of DNA polymerase. N6-Methyl-dATP is often used to study the fidelity mechanism of DNA replication and the influence of methylation on nucleic acid interactions. It can be used as a probe to explore the regulation of methylation modification on enzyme activity, and also provides a tool for understanding how epigenetic modifications affect genomic stability. At the same time, it has potential research value in the design of antiviral drugs.
Physical Appearance | Solution |
Storage | Store at -20°C or below |
M.Wt | 505.2 (free acid) |
Formula | C11H18N5O12P3 (free acid) |
Synonyms | N6-Methyl-2'-deoxyadenosine-5'-Triphosphate |
Chemical Name | lithium (3-hydroxy-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl triphosphate |
SDF | Download SDF |
Canonical SMILES | OC1C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)OC(N2C=NC3=C2N=CN=C3NC)C1.[Li+].[Li+].[Li+].[Li+] |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity ≥90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
