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N-Benzylacetamidine (hydrobromide)

Catalog No.
C3084
iNOS inhibitor
Grouped product items
SizePriceStock Qty
5mg
$71.00
Ship with 5-10 days
10mg
$138.00
Ship with 5-10 days
50mg
$576.00
Ship with 5-10 days
100mg
$1,009.00
Ship with 5-10 days

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Email: [email protected]

Worldwide Distributors

Background

IC50: 0.20 μM: inhibits inducible nitric oxide synthases (iNOS).

IC50: 350 μM: blocks endothelial nitric oxide synthases (eNOS).

N-Benzylacetamidine is a potent and selective inhibitor of iNOS compared to eNOS. NOS is essential to the formation of nitric oxide (NO) via the NADPH- and O2-dependent oxidation of L-arginine, which plays a role in regulating many pathological and physiological processes, including smooth muscle relaxation and neurotransmission. INOS contributes to immune response and inflammation while eNOS plays a vital role in regulating vascular tone.

In vitro: N-Benzylacetamidine showed good iNOS and almost negligible eNOS inhibition in THP-1 cells, a human myelomonocytic leukemia cell line [1].

In vivo: Up to now, in vivo study of N-Benzylacetamidine is still in the development stage.

Reference:
[1].  Maccallini, C., Patruno, A., Besker, N., Ali, J., Ammazzalorso, A., & De Filippis, B. et al. Synthesis, Biological Evaluation, and Docking Studies of N-Substituted Acetamidines as Selective Inhibitors of Inducible Nitric Oxide Synthase. Journal of Medicinal Chemistry. 2009; 52(5): 1481-1485.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt229.1
Cas No.186545-76-6
FormulaC9H12N2 · HBr
Solubility≤25mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide
Chemical NameN-(phenylmethyl)-ethanimidamide, monohydrobromide
SDFDownload SDF
Canonical SMILESCC(NCC1=CC=CC=C1)=N.Br
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.

Quality Control

Quality Control & MSDS

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Chemical structure

N-Benzylacetamidine (hydrobromide)