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Methyllycaconitine citrate

Catalog No.
B6556
α7-containing neuronal nicotinic receptors antagonist
Grouped product items
SizePriceStock Qty
5mg
$106.00
In stock
25mg
$347.00
Ship with 5-10 days

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Email: [email protected]

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Background

Methyllycaconitine citrate(MLA) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 1.4 nM)[1,2]. 

MLA inhibits the decreased cell viability induced by Aβ25-35, pretreatment with 5 and 10 µM. Aβ25-35 treatment increases LC3-II levels, which is inhibited by administration of Methyllycaconitine citrate. MLA also inhibits Aβ-induced autophagosome accumulation in SH-SY5Y cells[3]. 

MLA inhibits methamphetamine(METH)-induced climbing behavior by 50%. MLA prevents a decrease in striatal synaptosome dopamine (DA) uptake, MLA significantly attenuates METH-induced neurotoxicity at 72 h post-treatment. MLA fully prevents microglial activation at 24 h post-treatment and tending to confirm its neuroprotective activity[4]. 

References:

[1]. Kalappa B I, Sun F, Johnson S R, et al. A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia. Brit.J.Pharmacol, 2013, 169(8): 1862-1878.

[2]. Ward J M, Cockcroft V B, Lunt G G, et al. Methyllycaconitine: A selective probe for neuronal α-bungarotoxin binding sites. FEBS Lett, 1990, 270(1-2): 45-48 .

[3]. Zheng X, et al. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. PLoS One, 2014, 9(10): e111536.

[4]. Escubedo E, et al. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. J Pharmacol Exp Ther, 2005, 315(2): 658-67.

Product Citation

Chemical Properties

Physical AppearanceWhite solid
StorageDesiccate at -20°C
M.Wt874.93
Cas No.112825-05-5
FormulaC37H50N2O10·C6H8O7
SolubilitySoluble in DMSO
SDFDownload SDF
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Methyllycaconitine citrate

Related Biological Data

Methyllycaconitine citrate