In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Mecamylamine hydrochloride is a non-selective, non-competitive nAChR antagonist, has oral activity, and has certain therapeutic effects on various neuropsychiatric diseases. It can easily cross the blood-brain barrier[1,2].
At a holding potential of –70 mV, mecamylamine (1-20 μM) reduces the amplitude of the induced end plate current (EPC), the Hill constant is equal to 1.2, IC50 = 7.8 μM] .
Mecamylamine (0.5-1 mg/kg; Intraperitoneal injection; C57BL/6J mice) has antidepressant-like effects on both the TST and FST and these effects are dependent on the β2 and α7 subunits.
. Bacher I, et al. Mecamylamine-a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009, 10(16): 2709-21.
. Ostroumov K, et al. Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur Biophys J. 2008, 37(4): 393-402.
. Rabenstein R L, et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006 Dec, 189(3): 395-401.
|Physical Appearance||A solid|
|Storage||Desiccate at RT|
|Solubility||≥20.4mg/mL in Ethanol|
|Chemical Name||(1R,2S,4S)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride|
|Canonical SMILES||CC([[email protected]@H]1C[[email protected]]2CC1)(C)[[email protected]@]2(C)NC.Cl|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|