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Mecamylamine hydrochloride

Catalog No.
nicotinic acetylcholine receptor antagonist
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Mecamylamine hydrochloride is a non-selective, non-competitive nAChR antagonist, has oral activity, and has certain therapeutic effects on various neuropsychiatric diseases. It can easily cross the blood-brain barrier[1,2]. 

At a holding potential of –70 mV, mecamylamine (1-20 μM) reduces the amplitude of the induced end plate current (EPC), the Hill constant is equal to 1.2, IC50 = 7.8 μM] [2]. 

Mecamylamine (0.5-1 mg/kg; Intraperitoneal injection; C57BL/6J mice) has antidepressant-like effects on both the TST and FST and these effects are dependent on the β2 and α7 subunits[3]. 


[1]. Bacher I, et al. Mecamylamine-a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009, 10(16): 2709-21.

[2]. Ostroumov K, et al. Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur Biophys J. 2008, 37(4): 393-402.

[3]. Rabenstein R L, et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006 Dec, 189(3): 395-401.

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at RT
Cas No.826-39-1
Solubility≥20.4mg/mL in Ethanol
Chemical Name(1R,2S,4S)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
SDFDownload SDF
Canonical SMILESCC([[email protected]@H]1C[[email protected]]2CC1)(C)[[email protected]@]2(C)NC.Cl
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

Mecamylamine hydrochloride