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M-CSF, human recombinant protein

Catalog No.
M-SCF, hematopoietic growth factor, expressed in E.Coli, active in the mouse.
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Email: [email protected]

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Macrophage Colony stimulating Factor (M-CSF) is a hematopoietic growth factor produced by lymphocytes, monocytes, fibroblasts, macrophages, bone marrow stromal cells and endothelial cells. M-CSF plays important roles in regulating cell proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their respective progenitor cells. M-CSF also enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines from macrophages. MCSF plays critical roles in bone metabolism, immunological defenses, lipoproteins clearance, fertility and pregnancy.

The human M-CSF cDNA encodes a 554 aa protein contains a 32 aa signal sequence. Human M-CSF is active in the mouse, while mouse M-CSF is species-specific. Recombinant human M-CSF is a 36.8 kDa homodimeric protein containing two 159 amino acid polypeptide subunits.

Biological Activity

Determined by the dose-dependent stimulation of the proliferation of murine M-NSF-60 cells.
ED50 < 5.0 ng/ml.          
Specific activity > 2*105 units/mg.          

Quality Control

Quality Control & DataSheet

View current batch:
    Purity: ≥98%, by SDS-PAGE and HPLC.
    Endotoxin Level:< 0.1 ng/μg


Gene ID: 1435 Accession #: P09603
Alternate Names:Human M-CSF, M-CSF, MCSF, M CSF, h-M-CSF, rh-M-CSF, recombinant human M-CSF, recombinant M-CSF.
Source: Escherichia Coli. M.Wt: 36.8 kDa
Appearance: Lyophilized protein Storage: Store at -20°C
Formulation:Sterile filtered and then lyophilized from 5 mM Tris, pH 8.0 + 80 mM Arginine.
Solubility:Reconstitute in water to a concentration of 0.1-0.5 mg/ml. The solution can then be diluted into other aqueous buffers and stored at +4°C for 1 week and -20℃ for future use.
Shipping Condition: Gel pack. Handling: Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.