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LEP (116-130) (mouse) An antiobesity hormone

Catalog No.A1024
Size Price Stock Qty
Leptin (116-130), amide, mouse 1mg
In stock
Leptin (116-130), amide, mouse 5mg
In stock
Leptin (116-130), amide, mouse 10mg
In stock
Leptin (116-130), amide, mouse 25mg
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

LEP (116-130) (mouse)

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Chemical Properties

Cas No. 258276-95-8 SDF Download SDF
Synonyms Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser
Chemical Name LEP (116-130) (mouse)
Formula C64H109N19O24S M.Wt 1560.73
Solubility >156mg/mL in DMSO Storage Desiccate at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.


Leptin (116-130), amide, mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis. Leptin deficiency or resistance can result in profound obesity, diabetes, and infertility in humans. Since the discovery of leptin, the breadth of biological actions has dramatically expanded and served to broaden the initial perspective, where this protein was viewed solely as an antiobesity hormone. Important biological activities have been discovered in peripheral tissues that demonstrate the pleiotropic effects of this molecule in such areas as hematopoiesis, angiogenesis, blood pressure, bone mass, lymphoid organ homeostasis, and T lymphocyte function. Recent data indicate that leptin(116-130), an active fragment of the native molecule, exerts effects similar to those of the native peptide on body weight and food intake.



Figure1  Formula of Leptin (116-130)



Figure2  Signal transduction pathways of leptin


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4. Margetic S, Gazzola C, Pegg GG, Hill RA (2002). "Leptin: a review of its peripheral actions and interactions". Int. J. Obes. Relat. Metab. Disord. 26 (11): 1407–1433.