L-689,560
Catalog No.
B6430
potent NMDA antagonist
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L-689,560 (CAS: 139051-78-8) is a potent antagonist selective for the glycine-binding site of the NMDA receptor, with an affinity (K_b) of 130 nM. This tetrahydroquinoline derivative preferentially inhibits NMDA receptor activity via blockade at the glycine site, demonstrating over three orders of magnitude selectivity compared to glutamate site targeting. L-689,560 radiolabeled analogues ([^3H]-L-689,560) are utilized as highly selective ligands for studying glycine site interactions in vitro. This compound serves as an experimental tool in neurological research, particularly in models investigating ischemic cerebral damage and seizure susceptibility. No clinical studies have been reported.
| Physical Appearance | White solid |
| Storage | Store at RT |
| M.Wt | 380.23 |
| Cas No. | 139051-78-8 |
| Formula | C17H15Cl2N3O3 |
| Solubility | ≥20.9 mg/mL in DMSO; ≥42 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | (2S,4S)-5,7-dichloro-4-(3-phenylureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | ClC1=C2[C@H](C[C@@H](C(O)=O)NC2=CC(Cl)=C1)NC(NC3=CC=CC=C3)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
