L-161,982
Catalog No.
B7088
EP4 receptor antagonist
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L-161,982 (CAS 147776-06-5) is a selective antagonist of the prostaglandin E2 receptor subtype EP4. By specifically blocking EP4 signaling, this compound modulates downstream pathways associated with inflammation and cell proliferation. In vitro studies indicate that inhibition of EP4 by L-161,982 reduces ERK phosphorylation and consequently suppresses proliferation of the HCA-7 cell line. Additionally, rodent studies demonstrate that L-161,982 alleviates collagen-induced arthritis, underscoring its utility in investigating EP4-related inflammatory processes and disease mechanisms.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 654.72 |
| Cas No. | 147776-06-5 |
| Formula | C32H29F3N4O4S2 |
| Solubility | ≥57.9 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | N-((4'-((3-butyl-5-oxo-1-(2-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-4(5H)-yl)methyl)-[1,1'-biphenyl]-2-yl)sulfonyl)-3-methylthiophene-2-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | FC(F)(C1=CC=CC=C1N2N=C(CCCC)N(C2=O)CC(C=C3)=CC=C3C4=CC=CC=C4S(=O)(NC(C5=C(C)C=CS5)=O)=O)F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity ≥95.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
